Your brain is designed to learn, adapt, and manage stress throughout life. As we age, memory, sleep quality, and emotional resilience may decline. Supporting brain magnesium levels helps maintain these vital functions. Magtein (magnesium L-threonate) has been studied for its ability to support memory, sleep, and stress regulation.*
What Is Magtein?
Magtein is a patented form of magnesium L-threonate, developed by neuroscientists to improve magnesium’s ability to cross the blood-brain barrier and increase brain magnesium concentrations.*
Magnesium supports hundreds of biochemical reactions tied to cognition, sleep, and mood.* Standard forms such as oxide, citrate, and glycinate do not easily reach the brain. Clinical research on Magtein shows its unique ability to elevate brain magnesium levels and support cognitive performance in adults.*
Memory and Cognitive Performance
A 12-week randomized, double-blind, placebo-controlled trial by Liu et al. examined magnesium L-threonate in adults aged 50-70 with mild memory complaints. Participants took the supplement daily and completed memory, attention, and executive function tests.
Key Findings:
- Working memory, attention, and executive function improved compared with placebo.
- Some measures approached the performance of healthy, age-matched peers.
- Brain magnesium levels increased, confirming effective absorption into brain tissue.
These findings suggest magnesium L-threonate supports cognitive clarity and memory in older adults with mild cognitive concerns.*
Sleep Quality and Daytime Function
Beyond cognition, magnesium plays an important role in sleep regulation. A 2024 randomized controlled trial by Hausenblas et al. evaluated magnesium L-threonate in 80 adults aged 35–55 with self-reported sleep disturbances. Participants received 1 g/day for three weeks.
Key Findings:
- Participants reported more restful sleep and better mood upon waking.
- Wearable devices showed increased deep and REM sleep.
- No major adverse events were reported.
Magnesium L-threonate may support restorative sleep and balanced energy during the day.*
Stress, Mood, and Emotional Well-Being
Emerging research indicates that magnesium levels in the brain can influence mood and stress resilience. In the Hausenblas et al. trial, participants reported less irritability and greater calmness upon awakening.*
A 12-week clinical trial (NCT02363634) is assessing magnesium L-threonate’s effects on anxiety and mood in older adults. Early data suggest potential benefits for emotional balance and resilience as part of a healthy lifestyle.*
Safety and How to Use Magtein
The supplement is often taken in divided doses – morning and evening – to help maintain steady brain magnesium levels.* It can be taken with or without food and is generally well tolerated.*
Consult a healthcare provider before use if you are pregnant, nursing, taking medication, or have a medical condition. Benefits may take several weeks to appear as magnesium builds within brain tissue.*
What the Research Shows – and What’s Next
Current human trials support Magtein for:
- Memory and cognitive performance*
- Sleep quality and daytime alertness*
- Emotional balance and stress support*
However, most studies are short-term (3-12 weeks) and involve adults without severe cognitive or sleep disorders. Long-term studies in older adults and clinical populations are still ongoing.
To maintain compliance, any product claims should remain structure/function-based (e.g., “supports memory and sleep quality”) and not imply treatment or prevention of disease.*
The Takeaway
Human clinical research shows that Magtein can help support memory, improve sleep quality, and promote emotional balance in adults.* By restoring magnesium levels in the brain, it supports the foundation of healthy cognitive aging, focus, and stress resilience.*
References
- Liu G, Weinger JG, Lu ZL, et al. Magnesium-L-threonate supplementation improves memory and attention in older adults with cognitive complaints: a randomized, double-blind, placebo-controlled trial. J Alzheimers Dis. 2016;49(4):971–990.
- Hausenblas HA, Lynch T, Hooper S, et al. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: a randomized controlled trial. Sleep Med X. 2024;8:100121.
- ClinicalTrials.gov. Magnesium L-Threonate for Anxiety, Mood and Sleep Quality in Older Adults (NCT02363634). https://clinicaltrials.gov/ct2/show/NCT02363634
FDA Disclaimer
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.