Magtein Science

Rooted in science, Magtein stands out as a distinctive form of magnesium with unique properties. With an increasing number of published studies exploring its effects, Magtein has become a focal point in nutritional neuroscience. Guided by a Scientific Advisory Board that includes a Nobel Laureate. From its specialized absorption in the brain to its implications for memory and learning, Magtein offers a solution for supplement and wellness product manufacturers.

Magtein Bioavailability and Absorption

Magtein is the most bioavailable magnesium form to effectively increase the brain's magnesium levels.

Common magnesium forms including Magtein were tested to determine how effectively they cross the blood-brain barrier. After 24 days of supplementation, Magtein was the only compound tested that significantly raised the concentration of magnesium in the brain.

Additionally, Magtein was shown to be able to penetrate neuron cells better than other forms of magnesium, leading to an improvement in neural connections, also called synapse density.

Magtein - Chart showing different Magnesium forms in the brain.

Chart showing Magtein effect on four types of cognitive function.

Magtein was tested in a published human clinical trial for its effect on four types of cognitive function: executive function, working memory, episodic memory and attention.

Each area of the four types of cognitive function tested noted improvement. The overall score of cognitive ability had significant improvement over placebo at 6 and 12 weeks.

Change in composite score of cognitive function with Magtein supplementation.

Magtein® supports a healthy stress response in older adults

Magtein has also been studied for its effect on managing everyday stress. Complaints of everyday stress causing disruption to daily living, mood, tension and mental agitation were evaluated.

By Rafea Naffa, PhD — Director of R&D · August 12, 2026

References

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NOW PLAYING

Dr. Jennifer Gu

Dr. Jennifer Gu, Senior Vice President at ThreoTech LLC, recently spoke at Vitafoods India.  Her presentation provides an introduction to Magtein® and highlights the research efforts.  This comprehensive overview provides key milestones for Magtein® and the clinical evidence supporting the Magtein® benefits.  Magtein® (magnesium L-threonate) is a highly brain-bioavailable form of magnesium, developed to cross the blood-brain barrier and shown in preclinical research to raise brain magnesium levels — supporting synaptic density, plasticity, and cognitive function.

Regulatory Authorizations

Magnesium L-threonate holds a U.S. FDA GRAS notification (GRAS Notice No. 499), EU novel-food authorization (Commission Implementing Regulation (EU) 2024/2694), and UK Food Standards Agency novel-food authorization (RP-956, MAGTEIN® Magnesium L-Threonate).