Magtein® is the unique, patented form of magnesium L-threonate, shown in human clinical trials to support cognitive performance, healthy brain aging, and sleep — backed by 50+ peer-reviewed publications, 10+ human clinical trials, and 4 international industry awards.*
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Magtein® is proud to partner with Arnold’s Pump Club, Arnold Schwarzenegger’s daily newsletter and podcast, reaching millions of health-conscious readers. Together, we’re translating clinical research.
Magtein is designed to increase brain magnesium to healthy levels — a mechanism supported by preclinical research — supporting healthy brain aging and cognitive vitality.*
Magtein supports sleep quality, with clinical evidence of improved deep-sleep scores and feeling more refreshed upon awakening.
Magtein supports morning energy and daytime performance after sleep.*
Magtein supports overall cognitive performance, supported by improvements in composite cognitive scores.
Magtein supports cognitive reaction time.*
Magtein supports mental performance across everyday tasks, including fluid cognition and working memory.*
Not all forms of magnesium work the same way.
Uniquely designed to increase brain magnesium to healthy levels.**
Different magnesium forms deliver different elemental doses and may be absorbed differently throughout the body.
Supports working memory, cognitive performance, and fluid cognition.*
Lacks form-specific research on brain-targeted cognitive support.
Backed by 50+ peer-reviewed publications and 10+ human clinical trials.
The number, design and outcomes of studies differ across magnesium forms.
Well-studied and water-soluble, with good digestive tolerability.
Some commonly used forms are poorly absorbed by the body.
**Mechanism supported by preclinical research; not directly measured in human clinical trials.
Magtein® is backed by more than 15 years of brain health research, including 5+ randomized, double-blind, parallel-group controlled trials—a gold-standard approach to evaluating clinical efficacy.
Backed by more than 15 years of rigorous brain health research and gold-standard parallel-group controlled trials.
Neuroscientists led by Dr. Guosong Liu publish landmark research in the journal Neuron, identifying magnesium L-threonate (Magtein) as a novel compound shown to raise brain magnesium levels and improve learning and memory in animal models.¹
Magtein receives Generally Recognized as Safe (GRAS) status under FDA guidelines.
Magtein is approved for a registered trademark.
Magtein’s first published human clinical study reported improvements in executive function and processing speed in older adults.²
Health Canada issued an NPN for a Magtein formulation including an authorized claim supporting cognitive function in elderly adults with mild cognitive impairment.
A peer-reviewed clinical study found that a Magtein-based formula improved memory in healthy adults, with larger improvements reported among older participants.³
Magtein Magnesium L-Threonate was approved by FSSAI as a source of magnesium for Health Supplements and Nutraceuticals.
A clinical study found that Magtein improved sleep quality and daytime functioning in adults with self-reported sleep problems, including improvements in deep-sleep and REM-sleep scores, mood and alertness.⁴
Magtein is granted Novel Food status in the European Union, with a 5-year period of regulatory exclusivity.⁵
The Thai FDA approved Magtein as a source of magnesium in dietary supplements, subject to specified conditions of use.
A clinical study finds that Magtein improves cognitive performance in adults, measured by NIH Total Cognition Composite scores versus placebo after 6 weeks.⁶
Magtein is authorized as a Novel Food across England, Scotland, and Wales, extending its 5-year regulatory exclusivity to the UK market.⁷
Health Canada issued NPN 80148813 for Magtein Powder, expanding authorized positioning to include support for normal nerve and brain function and nervous system function.
Magnesium L-threonate received Great Britain Novel Food authorization following a positive FSA assessment, enabling use in food supplements for adults under specified conditions.
References: 1. Slutsky I, et al. 2010. 2. Liu G, et al. 2016. 3. Wang Y. 2022. 4. Hausenblas HA, et al. 2024. 5. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) et al. 2024. 6. Lopresti AL, Smith SJ. 2026. 7. Food Standards Agency (UK). Novel food authorization: magnesium L-threonate monohydrate. 2026.
Magtein is the patented, proprietary form of magnesium L-threonate, uniquely designed to increase brain magnesium to healthy levels — a mechanism supported by preclinical research.* Backed by 50+ peer-reviewed publications and 10+ human clinical trials, Magtein is one of the most extensively studied brain-health magnesium ingredients available today.*
Magtein (magnesium L-threonate) differs from other magnesium forms — such as magnesium oxide, citrate, and glycinate — because it is brain-targeted delivery, water-soluble, and shown to have a favorable gastrointestinal tolerability profile.* Magtein is not blended with poorly absorbed forms like magnesium oxide, so every dose delivers pure Magtein.*
Magtein supports cognitive performance, executive functions and working memory, backed by human clinical research.* In three clinical trials, Magtein improved cognitive scores, with gains corresponding to younger estimated cognitive ages.*
Magtein supports cognitive vitality, with clinical trials reporting improvements in cognitive performance.*
Magtein has been clinically studied at 1–2 grams per day.* One gram of Magtein provides at least 72 mg of elemental magnesium, while 2 grams provides at least 144 mg.* Benefits are cumulative; clinical studies have reported sleep benefits within 3 weeks and cognitive benefits over 6–12 weeks of daily use. Results vary from person to person.*
Clinical studies show measurable benefits from Magtein in as little as 3 weeks, with most trials evaluating outcomes over 6–12 weeks.* Because benefits are cumulative, consistent daily use is recommended for the best results.*
Yes. Human clinical studies have assessed Magtein’s safety and tolerability and found it generally well tolerated at the doses and durations studied.
As with any magnesium source, individuals with significant renal impairment should use clinical caution, since magnesium is renally cleared.** Magnesium may also reduce the absorption of certain antibiotics and oral bisphosphonates, so spacing doses by at least 2 hours is generally recommended.** Magtein has not been specifically studied in pregnancy, lactation, or pediatric populations.*
Magnesium L-threonate holds a U.S. FDA GRAS Notice (GRN 499), with a “no questions” response for use as a source of dietary magnesium under specified conditions of use.* It’s important to understand what this does — and doesn’t — mean: dietary supplements, as a product category, are not reviewed or approved by the FDA before they reach the market. Under U.S. law (DSHEA), manufacturers are responsible for ensuring their products are safe, and the FDA’s role is primarily to act if a safety issue arises after a product is sold.* A GRAS Notice for an ingredient like magnesium L-threonate reflects the FDA’s review finding no safety concerns for that specific use — it is not an approval of Magtein or any finished product containing it, and it is not an efficacy determination.*
Yes. Magtein magnesium L-threonate was granted Novel Food status in the European Union in 2024, and in the United Kingdom (England, Scotland, and Wales) in 2026.*
Both EU and UK authorizations provide a five-year period of regulatory exclusivity for Threotech and its licensees. Magtein is also permitted for use in Canada, India, Turkey and Thailand, subject to each country’s conditions of use.*
Magtein is supplied to the same ingredient quality specifications worldwide.*
Magtein is an official partner of Arnold’s Pump Club, Arnold Schwarzenegger’s daily newsletter and podcast, reaching millions of health-conscious adults worldwide. Announced at Natural Products Expo West 2026, the partnership brings Magtein’s clinical research on magnesium L-threonate to Pump Club’s “positive corner of wellness” — translating real science on brain health and cognitive aging into the clear, practical guidance the community is built on. In June 2026, the partnership reached a defining moment at the Arnold’s Pump Club Hometown Event at the Arnold Schwarzenegger Museum in Thal, Austria — the town where Schwarzenegger’s own journey began.
The Magtein x Arnold’s Pump Club partnership was announced in March 2026 at Natural Products Expo West.
Both brands are built on the same principle — evidence over trends. Magtein’s clinical research on magnesium L-threonate aligns with Arnold’s Pump Club’s mission to deliver practical, science-backed health guidance to a global wellness audience.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
**These interaction and renal points reflect general pharmacology for magnesium as a mineral class, not findings from Magtein-specific interaction trials, which have not been conducted.
Magtein® is trusted by leading supplement brands around the world, including:
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