Wednesday, October 15, 2025

Understanding “Brain Age” and Cognitive Longevity

While chronological age is measured in years, brain age reflects how well your brain performs relative to your biological age. A person in their sixties, for instance, might have the mental sharpness of someone decades younger – or, conversely, may notice that memory and focus require a little more effort than before.

What is Brain Age?

Brain age isn’t a fixed measure. It’s influenced by genetics, lifestyle habits, nutrition, sleep quality, and how effectively the body manages stress. Over time, the brain naturally undergoes structural and chemical changes – including a gradual decline in synaptic density, changes in neurotransmitter activity, and reduced efficiency in neuronal communication. These shifts can affect how quickly we process information, form memories, and stay attentive.

The encouraging reality is that brain age can be supported. Through consistent, science-based lifestyle habits – such as regular physical activity, mental engagement, restorative sleep, and balanced nutrition – it’s possible to help maintain a “younger” cognitive profile well into later years.*

The Science of Cognitive Performance and Aging

Cognitive performance is the result of the brain’s ability to learn, adapt, and store new information – processes that depend on synaptic plasticity, or the flexibility and strength of connections between neurons.

Magnesium plays an essential role in supporting this process by helping regulate neuronal electrical activity and enzyme function involved in brain communication. However, brain magnesium levels tend to decline with age, and most dietary forms of magnesium are not efficiently absorbed into the brain due to the blood–brain barrier.

Magtein (magnesium L-threonate) was developed to effectively deliver magnesium to brain tissue, where it can support the cellular mechanisms underlying learning, memory, and cognitive flexibility.*

How Magtein May Help Support a Healthier “Brain Age”

Several human studies have investigated how magnesium L-threonate may support memory, learning, and attention – key components of cognitive performance.* By promoting healthy magnesium levels within brain cells, Magtein helps maintain neuronal density and supports the signaling pathways involved in focus and memory formation.*

Evidence from Human Studies on Magnesium L-Threonate

In a clinical study involving adults aged 50 to 70, daily supplementation with magnesium L-threonate was associated with improvements in cognitive performance measures and working memory compared to baseline results.* Participants also reported improved mood balance and reduced mental fatigue.*

Researchers suggest these findings may relate to magnesium’s ability to support synaptic plasticity – a foundational process for long-term brain health and adaptive learning.* By sustaining efficient communication between neurons, Magtein may help the brain “age better,” supporting clarity, recall, and resilience over time.*

Lifestyle Factors That Complement Magtein

Magtein can play a role in supporting cognitive health, but lifestyle and environmental choices remain equally important. Together, they create a foundation for maintaining an active and adaptable brain throughout life.

• Prioritize Quality Sleep: Deep sleep supports memory consolidation and helps clear metabolic byproducts from the brain. Maintaining consistent sleep–wake cycles reinforces cognitive balance.
• Engage in Mental Stimulation: Learning, reading, and creative pursuits challenge the brain, encouraging new neural connections.
• Move Regularly: Physical activity promotes healthy blood flow to the brain and stimulates growth factors that maintain neuron vitality.
• Manage Stress Thoughtfully: Chronic stress can influence neurotransmitter activity. Practices like meditation, deep breathing, and spending time outdoors can help promote calm and mental balance.
• Nourish the Brain: A nutrient-dense diet rich in magnesium-containing foods (such as leafy greens, legumes, and nuts), omega-3 fatty acids, and antioxidants supports overall brain function and resilience.

Together with Magtein, these habits can help support cognitive performance and healthy brain aging from multiple angles.*

References

1. Zhang C, Hu Q, Li S, Dai F, Qian W, Hewlings S, Yan T, Wang Y. A Magtein®, Magnesium L-Threonate–Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults. Nutrients. 2022;14(24):5235. doi:10.3390/nu14245235
2. Hausenblas HA, Lynch T, Hooper S, Shrestha A, Rosendale D, Gu J. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: a randomized controlled trial. Sleep Med X. 2024;8:100121.
3. Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010;65(2):165-177. doi:10.1016/j.neuron.2010.01.001
4. Liu G, Weinger JG, Lu ZL, Xue F, Sadeghpour S. Efficacy and Safety of MMFS-01, a synapse density enhancer, for treating cognitive impairment in older adults: a randomized, double-blind, placebo-controlled trial. J Alzheimers Dis. 2015;49(4):971-990.

FDA Disclaimer

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.