Posts Tagged :

magnesium l-threonate

Magtein® for Student Focus: Boosting Brain Power During Finals

 608 402 Riley Forbes
By:
0

Why Cognitive Support Matters During Finals

Finals season brings intense focus, long study hours, and heightened stress – conditions that challenge both the brain and body. Mental fatigue, disrupted sleep, and fluctuating energy levels can make it harder to retain information or perform under pressure. While students often turn to caffeine or stimulants for quick relief, these temporary boosts can also lead to energy crashes, anxiety, or restless nights.

Instead, supporting the brain’s natural processes for focus, learning, and recovery provides a more sustainable edge. Nutrients that enhance synaptic efficiency and relaxation – like magnesium L-threonate (Magtein) – can help the mind stay sharp while maintaining calm, balanced energy throughout the exam period.*

Stay calm and focused through finals. Magtein supports learning, memory, and balanced energy for sustained academic performance.

How Magtein Supports Student Focus

Magtein (magnesium L-threonate) is a unique form of magnesium developed by MIT researchers to raise magnesium levels specifically within the brain. Unlike other magnesium salts that act primarily in the gut or muscles, Magtein crosses the blood-brain barrier – enhancing neuronal communication and supporting the foundation of learning and memory.*

1. Enhances Learning and Memory Formation

Inside the brain, magnesium regulates NMDA and AMPA receptors – critical for synaptic plasticity, or the ability of neurons to strengthen and form new connections. During high-demand periods such as finals, these processes determine how efficiently information is learned and recalled. Maintaining optimal magnesium levels can help the brain process new material more effectively and consolidate memories during sleep.*

2. Promotes Calm Concentration

Excessive neural stimulation can lead to distraction, irritability, or “mental fog.” Magnesium helps stabilize excitatory neurotransmitters like glutamate and supports the production of GABA (gamma-aminobutyric acid), the brain’s main calming messenger. As a result, Magtein helps maintain focus without overstimulation, supporting calm alertness during study sessions and exams.*

3. Reduces the Effects of Academic Stress

Intense study routines can elevate cortisol levels and deplete magnesium stores. Research shows that magnesium plays a key role in regulating the hypothalamic-pituitary-adrenal (HPA) axis, the body’s stress-response system. By replenishing magnesium, Magtein supports a balanced physiological response to academic stress – helping students remain composed and resilient through long exam periods.*

Balanced magnesium levels promote steady focus, calm concentration, and mental clarity – helping students recharge between exams.

Timing Magtein for Maximum Focus and Recovery

Consistency matters more than the exact hour of intake, but timing can help maximize the desired effect.

  • Morning Use: Taking Magtein in the morning supports focus, cognitive performance, and task retention throughout the day. Pair it with breakfast for improved absorption and steady energy.*
  • Evening Use: For students who struggle with restlessness, taking Magtein 30-60 minutes before bedtime may promote relaxation and improve sleep quality. Deep sleep consolidates memory and prepares the brain for next-day learning.*
  • Consistent Daily Use: Regular intake maintains stable brain magnesium levels, supporting cumulative benefits for learning and mental clarity.*

Synergistic Study Habits for Brain Performance

Magtein works best as part of a holistic approach to learning and recovery. To optimize cognitive performance during finals week, combine magnesium support with evidence-based study and lifestyle strategies:

  • Structured Study Blocks: Focused, time-bound sessions (such as 50-minute blocks) help reduce burnout and maintain retention.
  • Sleep Optimization: Deep sleep is essential for memory consolidation and neural repair. Aim for 7-9 hours nightly to reinforce magnesium-dependent brain recovery.*
  • Nutrition for Cognitive Endurance: Prioritize whole grains, leafy greens, and omega-3-rich foods like salmon or walnuts. These supply essential nutrients for energy metabolism and brain cell integrity.*
  • Movement and Microbreaks: Light physical activity increases cerebral blood flow and relieves tension, helping reset focus between study periods.
Pairing Magtein with mindful movement like yoga supports calm focus, cognitive balance, and sustained mental performance during demanding study periods.

The Student Advantage: Brain Health Beyond Exams

While Magtein is often highlighted for its role in focus and memory, its benefits extend well beyond finals week. Maintaining optimal brain magnesium levels supports clarity, learning efficiency, and cognitive flexibility long-term. Students who build these habits early can cultivate greater mental resilience and academic confidence – skills that translate to lifelong performance and well-being.*

Summary: Smarter Study, Stronger Focus

Academic performance depends not only on hard work but also on how effectively the brain functions under stress. Magtein provides nutritional support for focus, calm energy, and cognitive clarity – helping students learn efficiently, recall accurately, and rest deeply when it matters most. By pairing magnesium support with smart study habits and restorative sleep, students can optimize both mental endurance and overall well-being during finals season – and beyond.*

References

  1. Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010;65(2):165-177.
  2. Liu G, Weinger JG, Lu ZL, Xue F, Sadeghpour S. Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. J Alzheimers Dis. 2016;49(4):971-990. doi:10.3233/JAD-150538 
  3. Hausenblas HA, Lynch T, Hooper S, Shrestha A, Rosendale D, Gu J. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial. Sleep Med X. 2024;8:100121. Published 2024 Aug 17. doi:10.1016/j.sleepx.2024.100121
  4. Hewlings SJ, Kalman DS. A randomized, double-blind, placebo-controlled, comparator trial evaluating Magtein® magnesium supplement on quality of life as related to levels of stress, anxiety, fear and other indicators. J Am Coll Nutr. 2022;41(7):673-683.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

What Are Nootropics and How Does Magtein® Fit In?

 806 534 Riley Forbes
By:
0

Understanding Nootropics

The term nootropics refers to nutrients and compounds that support cognitive performance, including memory, focus, learning, and mental clarity. The word originates from the Greek noos (mind) and tropos (to turn or guide), emphasizing their role in optimizing brain function.

While the concept of “smart drugs” has been popularized in media, true nootropics focus on long-term brain support rather than short-term stimulation. Nutrients, amino acids, and botanicals with neuroprotective and neuro-supportive properties can all fall under this category.

Clinically studied nootropics often support one or more of the following mechanisms:

  • Enhancing neurotransmitter balance (acetylcholine, GABA, dopamine)
  • Supporting neuroplasticity and synaptic efficiency
  • Reducing oxidative stress and inflammation
  • Optimizing cerebral blood flow and energy metabolism*
Balanced brain function begins with proper support. Nootropics like Magtein help sustain focus, learning, and cognitive resilience naturally.

In particular, natural nootropics such as citicoline, L-theanine, Bacopa monnieri, and magnesium L-threonate (Magtein) each influence distinct pathways within the brain.*

How Nootropics Support Brain Function

The brain requires immense energy and precise communication between billions of neurons to function optimally. Nootropics help sustain this efficiency through several mechanisms:

  1. Neurotransmitter Modulation: Nootropics influence the release and uptake of key messengers like glutamate, acetylcholine, and GABA – balancing stimulation and relaxation for improved focus and calm alertness.*
  2. Neuroplasticity and Synaptic Density: Certain compounds, such as magnesium L-threonate, promote synaptic plasticity – the brain’s ability to form and strengthen connections. This is crucial for learning, adaptability, and memory retention.*
  3. Energy Metabolism and Mitochondrial Support: The brain consumes nearly 20% of the body’s energy. Nutrients like magnesium and B vitamins assist in ATP production, supporting sustained cognitive endurance and reduced mental fatigue.*
  4. Neuroprotection: By buffering oxidative stress and supporting cellular repair, nootropics contribute to long-term brain health and resilience – especially under conditions of stress or aging.*
Healthy synaptic communication supports memory and learning. Magtein helps maintain magnesium levels essential for optimal brain signaling.

Magtein: A Brain-Focused Form of Magnesium

Among the most researched nootropics is Magtein (magnesium L-threonate), developed by MIT researchers to specifically support brain magnesium levels. Unlike other magnesium salts that act primarily in the muscles or gut, Magtein crosses the blood-brain barrier, directly influencing neuronal activity and plasticity.*

Magnesium is essential for more than 600 enzymatic reactions and plays a central role in neurotransmission and synaptic regulation. Within the brain, it modulates NMDA (N-methyl-D-aspartate) and AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors, both of which are critical for learning and memory processes.

Clinical studies – including those published in Neuron (2010), Journal of Alzheimer’s Disease (2016), and Sleep Medicine X (2024) – have demonstrated that magnesium L-threonate supplementation may:

  • Support working memory, learning ability, and cognitive flexibility*
  • Promote relaxation and improve sleep quality through balanced neurotransmission*
  • Support focus and next-day mental clarity*

Because it enhances brain magnesium levels, Magtein fits naturally within the nootropic category as a foundation nutrient that optimizes neural efficiency and long-term cognitive health.*

Integrating Nootropics Into a Healthy Routine

Nootropics work best when integrated into a holistic lifestyle that includes:

  • Balanced Nutrition: Emphasize whole foods, omega-3 fats, and magnesium-rich vegetables.
  • Consistent Sleep: Deep sleep consolidates memory and supports magnesium-dependent brain repair.
  • Mental Engagement: Learning new skills, reading, or practicing mindfulness reinforces neural pathways that nootropics help support.*
  • Stress Regulation: Chronic stress depletes magnesium and affects focus – making restorative practices essential.*

Magtein complements these practices by maintaining healthy neuronal signaling and enhancing the brain’s ability to adapt, learn, and recover from daily stressors.*

By using Magtein daily, you support mental clarity, mood balance, and long-term cognitive wellness- therefore helping maintain the foundation of healthy aging.

Summary: Building a Smarter, Resilient Brain

Nootropics represent a forward-looking approach to cognitive health – supporting the brain’s natural capacity to perform, adapt, and recover. Within this landscape, Magtein (magnesium L-threonate) stands out as a scientifically supported, foundational nootropic that nourishes brain pathways from the cellular level up. By combining consistent magnesium support with nutrient-dense foods, quality sleep, and daily mental engagement, individuals can foster long-term focus, memory, and emotional resilience.*

References

  1. Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010;65(2):165-177.
  2. Liu G, Weinger JG, Lu ZL, Xue F, Sadeghpour S. Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. J Alzheimers Dis. 2016;49(4):971-990. doi:10.3233/JAD-150538 
  3. Hausenblas HA, Lynch T, Hooper S, Shrestha A, Rosendale D, Gu J. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial. Sleep Med X. 2024;8:100121. Published 2024 Aug 17. doi:10.1016/j.sleepx.2024.100121
  4. Hewlings SJ, Kalman DS. A randomized, double-blind, placebo-controlled, comparator trial evaluating Magtein® magnesium supplement on quality of life as related to levels of stress, anxiety, fear and other indicators. J Am Coll Nutr. 2022;41(7):673-683.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

11 Signs You’re Magnesium Deficient

 760 508 Riley Forbes
By:
0

Understanding Magnesium Deficiency

Magnesium is involved in more than 300 enzymatic reactions critical to human health, influencing everything from energy production and nerve transmission to DNA synthesis and stress regulation. Despite its widespread importance, magnesium deficiency remains common, with research suggesting that roughly 50-70% of adults fall short of the recommended daily intake. This shortfall may occur quietly, gradually altering the body’s physiology long before blood levels reflect deficiency. Recognizing the subtle, interconnected signs of low magnesium can help you take proactive steps toward restoring balance through diet, lifestyle, and evidence-based supplementation.*

Maintaining healthy magnesium levels supports balanced energy, muscle performance, and overall vitality throughout daily activities.

1. Muscle Cramps and Spasms

Magnesium plays a key role in neuromuscular function by regulating the flow of calcium and potassium across muscle membranes. When magnesium levels drop, muscle cells can become overexcited, triggering involuntary contractions, spasms, or “charley horse” cramps. This imbalance may occur more frequently in athletes, older adults, or individuals with higher sweat losses. Supplementing with bioavailable forms of magnesium can help restore cellular electrolyte balance, allowing muscles to contract and relax efficiently.*

2. Fatigue and Low Energy

Every cell relies on magnesium to generate ATP – the body’s main source of energy. Within the mitochondria, magnesium stabilizes ATP molecules and supports enzymes responsible for oxidative phosphorylation. When magnesium is insufficient, these energy pathways operate less efficiently, often resulting in persistent fatigue, decreased exercise tolerance, or that “drained” feeling after minimal exertion. Over time, chronic low magnesium can disrupt metabolic flexibility, making energy recovery slower and less efficient.*

3. Brain Fog or Poor Focus

Cognitive clarity depends heavily on magnesium’s role in neural signaling and synaptic plasticity. This mineral modulates NMDA receptors – key regulators of learning, memory, and neural communication. Low magnesium can lead to excessive neuronal excitability, disrupting neurotransmitter balance and impairing information processing. Magnesium L-threonate (Magtein®), a form shown to cross the blood–brain barrier, has been studied for its ability to raise brain magnesium levels and support cognitive resilience, focus, and recall.*

4. Sleep Disturbances

Magnesium contributes to healthy sleep architecture by supporting relaxation pathways and regulating circadian rhythm. It interacts with GABA receptors, promoting calm neural activity and smoother transitions between sleep stages. Low magnesium levels can elevate nighttime cortisol and sympathetic nervous system activity, leading to difficulty falling or staying asleep. Emerging evidence, including recent studies on magnesium L-threonate, suggests that supporting brain magnesium may enhance deep sleep and reduce nighttime awakenings.*

Adequate magnesium promotes relaxation and supports deep, restorative sleep essential for recovery and focus.

5. Anxiety or Mood Changes

The relationship between magnesium and mood is both biochemical and physiological. Magnesium modulates the HPA (hypothalamic–pituitary–adrenal) axis, which governs the body’s stress response. Insufficient levels can amplify excitatory signaling through glutamate pathways while dampening GABAergic tone – creating a neurochemical environment associated with anxiousness or irritability. Several studies have found that magnesium supplementation supports calmness and emotional resilience by restoring neurotransmitter balance and regulating cortisol rhythms.*

6. Headaches or Migraines

Magnesium’s influence on vascular tone and nerve excitability makes it a central factor in headache regulation. Deficiency can cause cerebral arteries to constrict and increase the release of pain-mediating neurotransmitters like substance P. This dual effect may contribute to the onset of migraines or tension-type headaches. Clinical trials suggest magnesium supplementation – especially in bioavailable forms – may help maintain normal vascular reactivity and reduce the frequency of migraine episodes over time.*

7. Muscle Weakness

Beyond cramping, low magnesium can lead to general muscle fatigue and weakness. Because magnesium is essential for ATP-dependent muscle contraction and calcium reuptake, inadequate stores can cause early fatigue during exercise or prolonged recovery afterward. This effect is often compounded by electrolyte losses through sweat, particularly in endurance athletes. Restoring magnesium balance supports proper energy metabolism in muscle tissue and promotes efficient post-exercise recovery.*

8. Irregular Heartbeat

Magnesium is essential for the heart’s electrical stability. It acts as a natural calcium antagonist, preventing excessive intracellular calcium that can lead to arrhythmias. Low magnesium levels may disrupt cardiac conduction, occasionally manifesting as palpitations or skipped beats. Magnesium also contributes to the maintenance of healthy blood pressure and vascular tone – underscoring its foundational role in cardiovascular homeostasis.*

9. Numbness or Tingling

At the neurological level, magnesium helps regulate ion channels that influence nerve excitability and signal transmission. When levels are low, neurons may misfire, producing sensations of numbness, tingling, or “pins and needles.” These symptoms often appear in conjunction with other signs of deficiency and serve as early warnings that magnesium-dependent nerve function is being compromised.*

Magnesium supports healthy nerve signaling and muscle function – helping maintain strength, coordination, and resilience as we age.

10. Constipation or Digestive Changes

In the gastrointestinal tract, magnesium supports peristalsis—the rhythmic contractions that move food through the intestines. It also helps draw water into the bowel, keeping stool soft and regular. Deficiency can slow this process, leading to constipation or digestive discomfort. While dietary magnesium supports normal motility, certain forms such as magnesium citrate have a gentle osmotic effect that may help reestablish regularity when needed.*

11. Increased Sensitivity to Stress

Chronic stress depletes magnesium through hormonal and urinary pathways, creating a feedback loop that heightens reactivity to future stressors. Low magnesium amplifies sympathetic (“fight-or-flight”) activation, reduces parasympathetic (“rest-and-digest”) balance, and impairs sleep quality – all of which increase perceived stress. Replenishing magnesium supports a calmer physiological baseline, improving emotional regulation and resilience during demanding periods.*

Addressing Magnesium Deficiency

If several of these signs sound familiar, consider assessing your magnesium intake. Dietary sources – like leafy greens, legumes, nuts, seeds, and dark chocolate – remain foundational. For targeted support, well-absorbed forms such as magnesium glycinate or magnesium L-threonate (Magtein) can complement nutrition and promote calm focus, improved sleep, and cognitive function over time.*

Summary: The Foundational Role of Magnesium

Magnesium influences nearly every system in the body – from muscle activity and metabolism to cognition and mood. Because it supports so many processes, even small deficiencies can have widespread effects. Often, these imbalances develop gradually, yet they manifest through diverse symptoms that reflect the mineral’s far-reaching physiological importance. Fortunately, recognizing the early signs allows you to take proactive steps. By combining nutrient-dense foods, balanced lifestyle habits, and clinically studied supplementation, you can support healthy magnesium levels. As a result, energy production becomes more efficient, neural activity remains calm and focused, and cognitive performance can stay strong for the long term.*

References

  1. National Institutes of Health, Office of Dietary Supplements. Magnesium Fact Sheet for Health Professionals. Updated 2024.
  2. Gröber U, Schmidt J, Kisters K. Magnesium in Prevention and Therapy. Nutrients. 2015;7(9):8199–8226.
  3. Slutsky I, et al. Enhancement of Learning and Memory by Elevating Brain Magnesium. Neuron. 2010;65(2):165–177.
  4. Hausenblas HA, Lynch T, Hooper S, Shrestha A, Rosendale D, Gu J. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial. Sleep Med X. 2024;8:100121. Published 2024 Aug 17. doi:10.1016/j.sleepx.2024.100121

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Best Time of Day to Take Magtein® (Magnesium L-Threonate)

 602 600 Riley Forbes
By:
0

Magnesium plays a vital role in energy production, stress regulation, and cognitive performance. Among the many forms available, Magtein (magnesium L-threonate) stands out for its ability to cross the blood-brain barrier and raise magnesium concentrations in the brain.*

This unique property makes Magtein a preferred choice for supporting focus, learning, relaxation, and restorative sleep. Yet, one common question remains: When is the best time to take it – morning or evening?

The answer depends on your personal goals and routine. Understanding how Magtein interacts with your body’s natural rhythms can help you find the schedule that supports both cognition during the day and relaxation at night.*

How Magtein Works in the Body

Unlike many magnesium salts that mainly act in the gut or muscles, Magtein delivers magnesium directly to the central nervous system. L-threonic acid, a metabolite of vitamin C, enhances magnesium’s solubility and helps transport it into brain cells. Once absorbed, it supports neurotransmitter balance, neuronal signaling, and synaptic plasticity – the foundation of learning and memory.*Because brain magnesium levels rise gradually, Magtein’s benefits build over time. This means consistency matters more than the exact hour of intake. Regular use supports cognitive clarity, calmness, and overall neural function.*

Morning: Supporting Focus and Cognitive Clarity

Taking Magtein in the morning can help support mental alertness and concentration throughout the day. For many, this timing aligns with cognitive demands such as work or study.

Magnesium helps regulate NMDA receptors, which play a critical role in learning, memory, and balanced brain activity. These effects promote steady alertness – helping you stay focused without overstimulation.*

Tips for Morning Intake:

  • Take 1-1.5 grams of Magtein with or after breakfast to support absorption and comfort.
  • Pair it with omega-3 fatty acids or B vitamins to further enhance brain energy metabolism.*
  • Stay well-hydrated, as electrolyte balance supports magnesium transport.
Focused adult working in natural morning light, representing improved concentration with magnesium L-threonate.
Morning Magtein intake helps sustain focus, clarity, and calm productivity throughout the day.

Evening: Promoting Relaxation and Restorative Sleep

If your goal is relaxation or deeper rest, evening dosing may be best. Magnesium supports GABAergic activity, which helps calm neural excitability and prepare the body for sleep.*

In the 2024 Sleep Medicine X study, led by Heather Hausenblas, PhD, magnesium L-threonate supplementation improved sleep quality, reduced nighttime awakenings, and enhanced next-day alertness.*

While Magtein is not a sedative, it helps the nervous system unwind, supporting the transition into restorative sleep.

Tips for Evening Intake:

  • Take 1-1.5 grams of Magtein with dinner or 30-60 minutes before bed.
  • Create a calm environment: dim lights, stretch, or practice mindfulness.
  • Avoid caffeine or stimulant-containing supplements after mid-afternoon.
Person relaxing in dim evening light, symbolizing magnesium’s role in promoting calm and restorative rest.
Evening Magtein supports relaxation and restful sleep through balanced neural activity.

Why Consistency and Absorption Matter

Magnesium’s impact is cumulative – results appear with steady daily use rather than single doses. Consistent intake maintains magnesium levels in neural tissue, supporting long-term focus, sleep, and mood balance.*

Magtein can be taken with or without food. Some people prefer it with meals for digestive comfort, while others find faster absorption on an empty stomach. What matters most is routine – pairing it with a consistent part of your day, such as breakfast or your nighttime ritual.*Hydration, balanced nutrition, and adequate sleep further support magnesium’s roles in energy metabolism and neurotransmitter balance.*

Daily wellness routine setup with supplements and clock, highlighting consistent magnesium use for brain balance.
Consistency is key – daily Magtein use supports steady magnesium levels for long-term brain health.

Optimizing Your Routine: Practical Tips

  • For focus and productivity: Take Magtein in the morning or midday with water and balanced meals.
  • For relaxation and sleep: Take it an hour before bedtime as part of your nighttime routine.
  • For lasting results: Use Magtein daily – consistency enhances cumulative benefits.*

Magtein’s flexibility allows it to fit into diverse lifestyles. The key is aligning your dosing with your goals – mental clarity or deep relaxation – and maintaining regular use.*

Closing Summary

The best time to take Magtein depends on what you want to achieve. Morning dosing supports focus, memory, and cognitive energy, while evening intake promotes relaxation and restful sleep. The true benefit lies in steady, consistent use. Combined with nutrient-dense meals, mindfulness, and restorative sleep habits, Magtein supports long-term cognitive resilience and calm mental performance – helping your brain function at its best every day.*

References

  1. Slutsky I, et al. Enhancement of Learning and Memory by Elevating Brain Magnesium. Neuron. 2010;65(2):165–177.
  2. Liu G, Weinger JG, Lu ZL, Xue F, Sadeghpour S. Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. J Alzheimers Dis. 2016;49(4):971-990. doi:10.3233/JAD-150538
  3. Hausenblas HA, Lynch T, Hooper S, Shrestha A, Rosendale D, Gu J. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial. Sleep Med X. 2024;8:100121. Published 2024 Aug 17. doi:10.1016/j.sleepx.2024.100121
  4. National Institutes of Health (NIH). Magnesium – Fact Sheet for Health Professionals. https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/. Accessed 2025.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Magnesium and Memory: The Connection Between Recall and Cognition

 930 522 Riley Forbes
By:
0

Magnesium is one of the most abundant minerals in the human body, yet its importance for brain health is often underestimated. Beyond supporting muscles, nerves, and energy production, magnesium plays a vital role in the processes that underlie learning, recall, and cognitive performance. Emerging research – particularly on Magtein® (magnesium L-threonate) – suggests that maintaining healthy magnesium levels in the brain may be essential for memory and long-term cognitive resilience.*

Magnesium, especially Magtein, supports memory and cognitive clarity in adults.

Why Magnesium Matters for the Brain

Inside the brain, magnesium supports more than 600 enzymatic reactions, many of which are directly tied to neural activity. It regulates the flow of ions like calcium and glutamate across nerve cells. This helps stabilize communication between neurons and prevents overstimulation.

One of magnesium’s most important functions involves the NMDA (N-methyl-D-aspartate) receptor. This receptor is critical for synaptic plasticity – the brain’s ability to form, strengthen, or weaken neural connections in response to experience. Synaptic plasticity is the foundation of learning and memory formation. When magnesium levels are low, NMDA receptors can become overactive. This overactivity leads to excessive calcium influx and neural stress. Sufficient magnesium helps regulate receptor activity, promoting optimal signal transmission and long-term memory encoding.*

Magnesium also influences neurotransmitters such as GABA (gamma-aminobutyric acid), which supports relaxation and balanced brain wave patterns. This creates the internal environment necessary for focus, recall, and cognitive clarity. Additionally, magnesium modulates AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors. AMPA receptors mediate fast excitatory synaptic transmission, which is essential for synaptic plasticity, learning, and short-term memory formation.*

How Magnesium Supports Memory and Learning

Cognitive performance depends on a delicate balance of neuronal excitation and inhibition. Too much stimulation can impair focus, while too little can dull processing speed. Magnesium helps maintain this balance through several key mechanisms:

  • Synaptic Density and Plasticity: Magnesium supports the formation and pruning of synapses. This allows neurons to communicate more efficiently. Animal studies show that increasing brain magnesium levels enhances synaptic density in the hippocampus, the brain’s primary memory center.*
  • Mitochondrial Function: Magnesium is required for ATP production. This ensures neurons have sufficient energy to transmit and process information.
  • Neuroprotection: Adequate magnesium helps buffer oxidative stress and inflammation. Both oxidative stress and inflammation can impair brain performance over time.*
  • Cognitive Flexibility: By modulating NMDA and AMPA receptor activity, magnesium supports adaptability. This enhances the ability to shift attention, learn new skills, and store information effectively.*

Together, these mechanisms demonstrate why magnesium is essential not only for momentary mental clarity but also for maintaining cognitive function across the lifespan.

Magtein: A Brain-Focused Form of Magnesium

Most dietary magnesium forms, such as magnesium oxide or citrate, are absorbed into the bloodstream but have limited impact on brain magnesium levels. That’s where Magtein (magnesium L-threonate) stands apart.

Developed by MIT researchers, Magtein combines magnesium with L-threonic acid, a metabolite of vitamin C. This combination helps magnesium cross the blood-brain barrier more effectively. Clinical and preclinical studies suggest that Magtein can significantly increase magnesium concentrations within brain cells, directly influencing synaptic plasticity and memory formation.*

In one landmark study published in Neuron (2010), animals receiving magnesium L-threonate demonstrated improved learning ability, working memory, and short- and long-term recall. Follow-up human research has shown that daily supplementation with 1.5-2 grams of Magtein (providing 108-144 mg of elemental magnesium) can support cognitive clarity and memory retention, particularly in middle-aged and older adults.*

Healthy magnesium levels support sharper thinking, better memory, and vibrant social connection as we age.

While these findings are promising, it’s important to note that Magtein is not intended to treat or prevent cognitive decline. Instead, it supports the brain’s natural processes involved in memory and attention.*

Lifestyle Synergy: Building a Brain-Healthy Routine

Magnesium works best as part of an integrated approach to brain health. Combining nutrient-rich foods, consistent sleep, and mental engagement creates a foundation for optimal cognition. Consider incorporating:

  • Magnesium-rich foods: Spinach, pumpkin seeds, almonds, and legumes provide dietary magnesium that complements supplementation.
  • Quality sleep: Deep sleep stages consolidate memories. Consistent rest supports magnesium-dependent neural recovery.
  • Cognitive engagement: Learning new skills or engaging in stimulating conversation reinforces neural circuits that magnesium helps sustain.
  • Stress management: Mindfulness and exercise can reduce cortisol, supporting magnesium balance and neuroplasticity.*

The Bigger Picture: Magnesium and Nootropic Support

As interest in nootropics – nutrients and compounds that support cognitive performance – continues to grow, magnesium stands out as a foundational element. Its ability to enhance neural communication, stabilize mood, and promote clarity makes it a natural complement to other evidence-based cognitive nutrients.*

Lifestyle strategies like stress management and quality sleep enhance magnesium’s effect on memory and cognition.

Summary

Magnesium is a cornerstone of brain function. It supports energy production, synaptic communication, neuroprotection, and cognitive flexibility. Magtein (magnesium L-threonate) is uniquely designed to raise magnesium levels in the brain. This can enhance learning, memory encoding, and recall. Pairing magnesium with lifestyle strategies – including quality sleep, cognitive engagement, and stress management – supports optimal brain performance, long-term cognitive resilience, and overall neural health. Emerging research continues to clarify magnesium’s role in neuroplasticity, mood regulation, and attention. Altogether, this highlights magnesium’s essential place in a daily brain wellness routine.*

References

  1. Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010;65(2):165-177. doi:10.1016/j.neuron.2009.12.026
  2. Zhou X, Huang Z, Zhang J, et al. Chronic Oral Administration of Magnesium-L-Threonate Prevents Oxaliplatin-Induced Memory and Emotional Deficits by Normalization of TNF-α/NF-κB Signaling in Rats. Neurosci Bull. 2021;37(1):55-69. doi:10.1007/s12264-020-00563-x
  3. Hausenblas HA, Lynch T, Hooper S, Shrestha A, Rosendale D, Gu J. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial. Sleep Med X. 2024;8:100121. Published 2024 Aug 17. doi:10.1016/j.sleepx.2024.100121
  4. National Institutes of Health. Magnesium – Fact Sheet for Health Professionals. https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/. Accessed 2025.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

How Much Magtein® Should I Take?

 772 514 Riley Forbes
By:
0

Understanding Magnesium L-Threonate Dosage

One of the most common questions people ask about Magtein (magnesium L-threonate) is how much to take. The answer isn’t always simple. Because magnesium L-threonate is a specialized compound, the amount of elemental magnesium it provides differs from the total compound weight listed on supplement labels.

Understanding this difference helps you compare magnesium supplements accurately. It also ensures that your intake aligns with what has been studied in clinical research.*

Empower your wellness by understanding what’s really in your magnesium.

Elemental Magnesium vs. Total Compound: Why the Numbers Look Different

Each form of magnesium contains a different percentage of elemental magnesium – the pure magnesium your body can use. Magnesium oxide, citrate, glycinate, and L-threonate all vary in how much magnesium they deliver.

For Magtein, each gram of magnesium L-threonate provides roughly 7-8% elemental magnesium. That means a 2-gram dose delivers about 144 mg of elemental magnesium.

This can be confusing because supplement labels often list the total compound weight – for example, “2,000 mg of magnesium L-threonate.” However, that number doesn’t represent the actual amount of magnesium.The advantage of magnesium L-threonate lies not only in its magnesium content but also in its ability to cross the blood-brain barrier. This allows it to support brain magnesium levels more effectively than many other forms.*

Magtein Dosage in Clinical Research

Human studies have explored how different daily doses of Magtein affect brain function, mood, and sleep quality. Across multiple trials – including those published in Neuropharmacology (Slutsky et al., 2010), Journal of Alzheimer’s Disease (Liu et al., 2016), and Sleep Medicine X (Hausenblas et al., 2024) – participants typically took between 1.5 and 2 grams per day of magnesium L-threonate.

Here’s what these studies found:

  • 1.5 grams per day (approximately 108 mg elemental magnesium) supported cognitive function and mood balance in adults weighing 50-70 kg (110-155 lbs).
  • 2 grams per day (approximately 144 mg elemental magnesium) supported sleep quality, focus, and resilience in adults weighing 70-90 kg (155-200 lbs).
  • The compound was well-tolerated across studies, with mild gastrointestinal effects being rare and transient.

These results suggest that body weight may play a role in ideal dosing, though more research is needed to confirm this relationship.*

When to Take Magtein

Timing can affect how well your body absorbs magnesium. Most research protocols divided the total daily dose into two or three servings – for example, one dose in the morning and one in the evening.

Taking Magtein with or after a meal can support steady absorption. Many people also find that an evening dose aligns with magnesium’s natural role in helping the body relax before rest.*

More importantly, consistency matters. Regular use appears to support gradual increases in brain magnesium over time, as shown in clinical research.*

Daily habits matter most – create a magnesium routine that lasts.

How Magtein Differs from Other Magnesium Forms

Many magnesium supplements are formulated to support muscle relaxation, digestion, or general magnesium replenishment. Magtein is different. It was developed to elevate magnesium levels in the brain – an area that most magnesium forms struggle to reach.

This difference comes from its unique structure. Magtein combines magnesium with L-threonic acid, a metabolite of vitamin C that improves solubility and cellular transport. In published studies, this structure increased brain magnesium concentrations, which may support mental clarity, focus, and restorative sleep.*

Safety and Considerations

Magtein is considered safe for adults when used at the studied doses of 1.5-2 grams per day. Individuals with kidney disease or those taking medications that affect magnesium levels should consult a healthcare provider before use.

Because magnesium can have a gentle laxative effect in higher doses, starting at the lower end of the clinical range and gradually adjusting may help your body adapt comfortably.*

Remember, supplements should always complement – rather than replace – a balanced diet and healthy lifestyle. Adequate hydration, a magnesium-rich diet (including leafy greens, nuts, and legumes), and consistent sleep routines all work together to support overall wellness.*

Balanced nutrition and lifestyle habits complement Magtein supplementation. Pair magnesium-rich foods and a consistent sleep routine to support long-term brain and body wellness.

Key Takeaway: Science-Backed Dosing for Brain and Sleep Support

Magtein stands apart from other magnesium forms by combining advanced bioavailability with strong scientific support. Research suggests that 1.5-2 grams daily, taken in divided doses, can be an effective range for most adults. This dosage supports focus, relaxation, and restorative sleep as part of a healthy routine.*

References

  1. Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010;65(2):165–177.
  2. Liu G, Weinger JG, Lu ZL, et al. Chronic oral administration of magnesium-L-threonate improves learning and memory and upregulates synaptic plasticity-related proteins in aged rats. J Alzheimers Dis. 2016;49(4):953–966.
  3. Hausenblas HA, Lynch T, Hooper S, et al. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial. Sleep Med X. 2024;8:100121.
  4. National Institutes of Health (NIH). Magnesium – Fact Sheet for Health Professionals. https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/
  5. WebMD. Magnesium: Uses, Side Effects, Interactions, Dosage, and Warning. https://www.webmd.com/vitamins/ai/ingredientmono-998/magnesium/

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Signs and Symptoms of Magnesium Deficiency

 1024 690 Riley Forbes
By:
0

Magnesium is an essential mineral that plays a critical role in over 300 biochemical reactions in the human body. Despite its importance, many adults do not achieve optimal magnesium intake. Low magnesium levels can subtly impact physical and mental health, often manifesting through a range of signs and symptoms. Understanding these signals and supporting magnesium intake through diet and supplementation can help maintain overall wellness.*

Balanced meals rich in magnesium help support vitality and overall wellness at every age.*

What Is Magnesium Deficiency?

Magnesium deficiency, also known as hypomagnesemia, occurs when the body’s magnesium levels fall below what’s needed to support cellular and biochemical processes.

Because magnesium is mostly stored inside cells and bones, blood levels can remain “normal” even when total body stores are low. As a result, mild magnesium deficiency often goes undetected – manifesting subtly through fatigue, mood changes, muscle tension, or restless sleep before it becomes clinically measurable.

Low magnesium status may result from inadequate dietary intake, excessive losses through sweat or urine, gastrointestinal issues that reduce absorption, or increased needs due to stress, aging, or certain medications. Research indicates that 50-70% of adults consume less magnesium than the recommended daily allowance, making it one of the most common micronutrient shortfalls worldwide.*

Common Signs and Symptoms of Magnesium Deficiency

Magnesium deficiency can present in both mild and more pronounced ways. While the severity and specific symptoms vary by individual, common indicators include:

  • Muscle Cramps and Spasms: Magnesium regulates calcium and potassium in muscle cells. Low magnesium can increase excitability of muscles, leading to twitches, cramps, or spasms.
  • Fatigue and Low Energy: Magnesium is vital for ATP production – the energy currency of cells. Insufficient magnesium may result in feelings of tiredness or decreased endurance.
  • Sleep Disturbances: Magnesium modulates neurotransmitters involved in relaxation, such as GABA. Low levels can contribute to difficulty falling asleep, restless sleep, or reduced sleep quality.
  • Mood Changes: Magnesium influences NMDA and GABA receptor activity, impacting emotional regulation. Deficiency may contribute to irritability, anxiety, or difficulty managing stress.
  • Cardiovascular Irregularities: Magnesium supports heart rhythm and vascular tone. Inadequate magnesium intake can occasionally be linked to palpitations or increased blood pressure.
  • Cognitive Impairments: Magnesium-dependent enzymes are crucial for synaptic plasticity and memory formation. Low magnesium may subtly affect focus, learning, and short-term memory.
Adequate magnesium supports calm, restorative sleep and helps the body relax naturally.*

Why Magnesium Matters

Magnesium is a fundamental mineral involved in more than 300 enzymatic reactions in the body, spanning critical functions such as ATP production, DNA and RNA synthesis, and protein formation. Magnesium acts as a cofactor in energy metabolism, stabilizes ATP molecules, and supports phosphate transfer – all essential for cellular energy and function.

Neurologically, magnesium regulates neurotransmitter release and maintains excitatory-inhibitory balance in the brain. It influences NMDA (N-methyl-D-aspartate) and GABA (gamma-aminobutyric acid) receptor activity, which are key for synaptic plasticity, learning, and emotional balance. Cardiovascularly, magnesium helps preserve normal myocardial electrical activity, vascular tone, and blood pressure regulation.

Muscle health also depends on magnesium’s role in calcium handling within cells. Adequate magnesium ensures proper contraction and relaxation cycles, reducing the likelihood of cramping, spasms, or fatigue. Collectively, these functions illustrate why even mild magnesium insufficiency can influence sleep quality, cognitive clarity, muscle performance, and cardiovascular health.*

Integrative Brain-Focused Magnesium: Magtein®

Not all forms of magnesium are the same. Many common forms – like magnesium oxide or citrate – primarily act in the digestive tract and muscles. Magtein (magnesium L-threonate), however, was developed to support brain magnesium levels more effectively.

Magtein combines magnesium with L-threonic acid, a metabolite of vitamin C, allowing it to cross the blood-brain barrier and increase magnesium concentrations within neurons. Research suggests this may support healthy synaptic density, learning ability, and overall cognitive performance.*

In human studies, daily supplementation with 1.5–2 grams of magnesium L-threonate (providing 108-144 mg elemental magnesium) has been associated with:

  • Improved memory and executive function*
  • Support for sleep quality and relaxation*
  • Greater mental clarity during the day*

This makes Magtein a valuable addition for individuals seeking a more integrative approach – supporting both body-wide magnesium balance and brain-focused performance.*

Ensuring Adequate Magnesium Intake

Supporting healthy magnesium levels involves daily habits that combine nutrition, movement, rest, and thoughtful supplementation.

  1. Prioritize Dietary Sources: Choose magnesium-rich foods like spinach, Swiss chard, almonds, cashews, pumpkin seeds, black beans, lentils, quinoa, and brown rice. Including a mix of these foods daily helps meet magnesium needs naturally. They also provide nutrients such as vitamin B6 and antioxidants, which help the body use magnesium effectively.
  2. Support with Lifestyle Habits: Stay hydrated, move regularly, and maintain a consistent sleep schedule. Dehydration reduces magnesium transport, and intense exercise increases loss through sweat. Quality sleep helps magnesium support the nervous system’s repair and recovery processes.
  3. Address Low Magnesium Proactively: Some people – especially athletes, older adults, and those with digestive challenges – may need more than diet alone provides. Clinically studied supplements such as Magtein can support absorption and brain bioavailability. Consistent use with meals can help maintain magnesium-dependent processes tied to cognition, mood, and muscle function.*
  4. Monitor and Use Safely: Most people tolerate magnesium well, but higher doses can cause temporary digestive discomfort. Starting low and increasing slowly helps the body adjust. Those with kidney concerns or medications that affect magnesium should consult a healthcare professional before use.*

By combining magnesium-rich foods, lifestyle strategies, and evidence-based supplementation when appropriate, individuals can support magnesium status and overall wellness.*

Leafy greens, nuts, and legumes offer natural magnesium to help maintain healthy balance and energy.*

Key Takeaways

Magnesium supports energy production, brain and muscle performance, heart rhythm, and mood balance. Low magnesium can show up as fatigue, cramping, restless sleep, or irritability. Focusing on nutrient-dense foods and, when appropriate, brain-targeted forms like Magtein helps maintain resilience, focus, and calm throughout the day.*

References

  1. Volpe SL. Magnesium in disease prevention and overall health. Adv Nutr. 2013;4(3):378S-383S.
  2. Rosanoff A, Weaver CM, Rude RK. Suboptimal magnesium status in the United States: Are the health consequences underestimated? Nutr Rev. 2012;70(3):153-164.
  3. Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010;65(2):165–177.
  4. Liu G, Weinger JG, Lu ZL, et al. Chronic oral administration of magnesium-L-threonate improves learning and memory and upregulates synaptic plasticity-related proteins in aged rats. J Alzheimers Dis. 2016;49(4):953–966.
  5. Hausenblas HA, Lynch T, Hooper S, et al. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial. Sleep Med X. 2024;8:100121.
  6. National Institutes of Health (NIH). Magnesium – Fact Sheet for Health Professionals. https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/. Accessed 2025.


These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

What Is Sleep Quality? Insights from the 2024 Sleep Medicine Study

 926 614 Riley Forbes
By:
0

Quality sleep is foundational to cognitive clarity, physical restoration, and emotional balance. Yet despite sleeping for nearly one-third of our lives, many adults struggle to achieve truly restorative rest. The latest research is uncovering why – and how certain nutrients may support this essential biological rhythm.*

The Science of Sleep: More Than Rest

Sleep is an active, highly regulated process that allows the brain and body to restore balance and prepare for the demands of the next day. During sleep, the brain clears metabolic waste, repairs neural pathways, and consolidates memories. Meanwhile, the body engages in tissue repair, energy restoration, and immune regulation – processes vital to longevity and resilience.

These restorative events unfold through a pattern known as sleep architecture, which includes four distinct stages that repeat several times per night. Each stage serves a specific physiological purpose.

Stage 1: The Transition to Sleep

This light sleep stage acts as a bridge between wakefulness and rest. It typically lasts only a few minutes as muscles relax and brain waves begin to slow.

Stage 2: Light Sleep and Memory Processing

Stage 2 comprises about half of total sleep time. Here, the body temperature drops, heart rate slows, and short bursts of brain activity – called sleep spindles – support learning and memory integration.

Stage 3: Deep, Restorative Sleep

Often referred to as slow-wave sleep, this phase enables tissue repair, muscle recovery, and immune strengthening. Deep sleep supports metabolic balance and cardiovascular function, forming the foundation of physical restoration.

REM Sleep: The Brain’s Recharging Phase

Roughly 90 minutes after falling asleep, rapid eye movement (REM) sleep begins. This is the stage of vivid dreaming, when brain activity increases and emotional regulation occurs. REM sleep strengthens neural connections that influence creativity, focus, and decision-making.

Throughout the night, the ratio of deep to REM sleep shifts. Early cycles prioritize physical repair, while later cycles emphasize cognitive and emotional renewal. Understanding this dynamic pattern reveals why sleep quality – not just duration – plays a critical role in overall well-being.*

Inside the 2024 Sleep Medicine Study

The 2024 Sleep Medicine X study, led by Heather Hausenblas, PhD, explored how magnesium L-threonate (Magtein®) may influence sleep quality and daytime function in adults reporting poor sleep.

The randomized, double-blind, placebo-controlled trial enrolled healthy adults aged 35 to 55. Participants were assigned to take either magnesium L-threonate or a placebo daily for 21 days. None of the participants had major health conditions, ensuring the results reflected typical lifestyle-related sleep challenges.

Methods: Subjective and Objective Sleep Assessments

Throughout the study, researchers evaluated sleep quality using validated subjective and objective tools, including:

  • The Leeds Sleep Evaluation Questionnaire (LSEQ), which measures sleep latency, quality, and alertness upon waking.
  • The Restorative Sleep Questionnaire (RSQ), which captures how refreshed and restored participants felt after sleep.
  • The Insomnia Severity Index (ISI), assessing perceived sleep difficulties and their impact on daily function.
  • The Profile of Mood States (POMS), which evaluates mood and emotional balance.
  • Daily sleep diaries and Oura Ring data, providing objective insights into total sleep time, sleep stages, and efficiency.

Key Findings: Sleep and Daytime Improvements

By the end of the 21-day trial, participants taking magnesium L-threonate demonstrated meaningful improvements in several measures of sleep and daytime well-being compared to placebo:

  • Sleep quality scores improved, suggesting deeper, more restorative rest and fewer nighttime awakenings.*
  • Time spent in deep sleep increased, as shown through Oura Ring data and participant self-reports. Deep sleep plays a vital role in cellular recovery and immune function.*
  • Participants reported better morning alertness and mental clarity, indicating enhanced sleep efficiency and overnight recovery.*
  • Mood and irritability scores improved, reflecting magnesium’s role in supporting calm neural activity and balanced stress responses.*

Study Conclusions: Brain Magnesium and Restorative Sleep

The study authors concluded that magnesium L-threonate’s ability to elevate brain magnesium levels may influence pathways related to relaxation, circadian rhythm regulation, and overall sleep architecture. While more large-scale studies are needed to confirm these findings, this research offers promising evidence linking brain magnesium balance with restorative sleep quality.*

Participants supplementing with magnesium L-threonate reported deeper sleep and greater morning alertness in clinical studies.

Understanding Sleep Quality

When we talk about “good sleep,” we often think about duration, but true sleep quality is about more than hours spent in bed. It reflects how efficiently the brain and body cycle through the stages of sleep and how refreshed you feel upon waking.

According to the National Heart, Lung, and Blood Institute, high-quality sleep typically includes:

  • Falling asleep within 15-20 minutes of going to bed
  • Minimal nighttime awakenings
  • Consistent cycling through deep and REM sleep
  • Waking up feeling alert rather than fatigued

Factors like stress, screen exposure, irregular schedules, and nutrient imbalances can disrupt these patterns, leading to light or fragmented sleep. Over time, this can affect mood, focus, and metabolic health.

The 2024 Hausenblas study adds to the growing body of research suggesting that restoring sleep architecture – particularly deep and REM stages – may be one of the most effective ways to improve how you function during the day.*

Supporting Restorative Sleep Naturally

Sustaining high-quality sleep begins with consistent habits: maintaining regular bedtimes, limiting light exposure in the evening, and allowing time to unwind. Nutritional support can complement these routines, especially nutrients that interact with the brain’s relaxation pathways.*

Preliminary findings from the Hausenblas study suggest that magnesium L-threonate may:

  • Support relaxation before bed, helping the body prepare for rest*
  • Promote deeper sleep phases that enhance recovery and energy renewal*
  • Support next-day calmness and focus by maintaining balanced neural signaling*

Ongoing research will continue to clarify how magnesium influences these processes, but the emerging evidence supports the idea that maintaining optimal brain magnesium levels may play a role in restoring healthy sleep patterns over time.*

Evening habits – like relaxation routines and magnesium support – can help promote restorative, high-quality sleep.

The Restorative Power of Sleep

Sleep is more than a nightly reset – it’s a cornerstone of long-term health and performance. Each night of quality rest activates intricate biological processes that renew the mind and body. Deep sleep enhances cellular regeneration and immune resilience, while REM sleep supports memory consolidation, learning, and emotional balance. Together, these cycles orchestrate the brain’s ability to adapt, recover, and thrive.

Inadequate sleep, on the other hand, can subtly influence energy metabolism, cognitive flexibility, and even hormonal rhythms over time. Research continues to reveal how sufficient restorative sleep may help maintain metabolic balance, cardiovascular function, and cognitive performance – all essential components of healthy aging.*

The 2024 findings reinforce a growing scientific perspective: supporting sleep quality through lifestyle, mindfulness, and targeted nutritional strategies may be one of the most effective ways to promote both short-term vitality and long-term well-being.* By prioritizing restorative sleep, individuals are not only enhancing nightly recovery but also investing in their overall health foundation – one that supports resilience, clarity, and balanced living.*

References

  1. Hausenblas HA, Lynch T, Hooper S, et al. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial. Sleep Med X. 2024; 8:100121.
  2. ClinicalTrials.gov. Magnesium L-Threonate for Anxiety, Mood, and Sleep Quality in Older Adults (NCT02363634).
  3. National Heart, Lung and Blood Institute. Your Sleep/Wake Cycle. https://www.nhlbi.nih.gov/health/sleep/sleep-wake-cycle. Accessed 2025.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Your Optimal Sleep Routine: How to Prepare for Better Sleep (Featuring Magtein®)

 1024 683 Riley Forbes
By:
0

Sleep is the foundation of overall health, yet many people find it difficult to get enough truly restorative rest. Whether you’re balancing a busy schedule, caring for little ones, or staying up late scrolling through your phone, improving your sleep routine can enhance your mood, focus, and overall well-being.

Magnesium L-threonate (Magtein) may also play a supportive role in promoting deeper, more restorative sleep when combined with healthy lifestyle habits.*

Read on for science-backed strategies to improve sleep quality, along with practical tips for incorporating Magtein into your nightly routine.

Understanding Sleep and Its Importance

Sleep is far more than downtime – it’s an essential period when your body and brain repair and restore. During deep sleep:

  • The brain clears metabolic waste and strengthens neuronal connections.
  • Stress hormones such as cortisol are regulated, helping maintain balanced mood and emotional resilience.*
  • Cellular repair, muscle recovery, and memory consolidation occur naturally.

Insufficient sleep can disrupt cognitive performance, emotional stability, and physical health. Therefore, building a consistent, supportive sleep routine is one of the most effective ways to protect long-term wellness.*

A peaceful morning rest supports brain and body recovery. In turn, consistent sleep habits and healthy magnesium balance may promote relaxation and emotional well-being.*

Building a Sleep Routine

Consistency is key. A regular schedule helps your body anticipate rest, making it easier to fall asleep and wake up refreshed.

To create an effective routine:

  1. Wind down with mindfulness. Techniques like journaling or deep breathing can help quiet the mind and promote calm before bed.
  2. Go to bed and wake up at consistent times. Keeping a regular schedule strengthens your internal clock and improves overall sleep quality.
  3. Include calming pre-sleep rituals. Activities such as reading, stretching, or meditation help signal the body that it’s time to rest.
  4. Avoid heavy meals, caffeine, and alcohol before bed. Try to stop eating large meals or consuming caffeine and alcohol at least three hours before bedtime, as these can interfere with deep sleep.*
Creating a relaxing bedtime ritual – like reading before sleep – can help signal the body to unwind and prepare for deeper rest.*

Optimizing Your Sleep Environment

Your bedroom environment directly affects how easily you fall – and stay – asleep. Small adjustments can make a major difference.

  1. Keep it cool, dark, and quiet. A slightly cooler room, blackout curtains, and white-noise machines can help your body enter deeper stages of sleep.*
  2. Limit blue-light exposure. Screens emit blue light that suppresses melatonin, your natural sleep hormone. Therefore, reducing screen time an hour before bed or using blue-light filters supports a healthier circadian rhythm.*
  3. Choose comfortable bedding. Soft, breathable materials and a supportive mattress can reduce nighttime discomfort and promote better rest.
  4. Declutter your space. A clean, organized bedroom can help your mind relax and create a calming atmosphere for sleep.

Lifestyle Strategies for Better Sleep

Move During the Day

Regular physical activity supports deeper, more efficient sleep. However, try to complete vigorous exercise at least a few hours before bedtime to prevent temporary alertness.*

Manage Stress Mindfully

Chronic stress can elevate evening cortisol levels, making relaxation difficult. Practices such as mindfulness, breathing exercises, or journaling help calm the nervous system and prepare the mind for rest.*

Nourish with Magnesium-Rich Foods

Magnesium supports relaxation and a calm nervous system.* Include leafy greens, nuts, seeds, and whole grains in your diet.

Moreover, magnesium L-threonate is a highly bioavailable form of magnesium that has been studied for its potential to support deep sleep and mental calm by helping magnesium cross the blood-brain barrier.*

Preparing colorful, magnesium-rich meals with leafy greens, nuts, and seeds supports muscle relaxation and a calm nervous system.*

How Magtein May Support Sleep and Cognitive Health

Research suggests magnesium L-threonate helps maintain brain magnesium levels, supporting relaxation, mood balance, and cognitive performance.*

Specifically, it may:

  • Encourage a calm and relaxed state before bed*
  • Support restorative sleep quality and deep sleep stages*
  • Promote next-day mental clarity and cognitive function*

Furthermore, human studies have explored its role in supporting mood, stress regulation, and sleep quality, making it a valuable addition to a holistic sleep routine.*

Putting It All Together: Your Optimal Sleep Routine

  • Optimize your environment: Keep your room cool, dark, and quiet.
  • Maintain consistency: Go to bed and wake up at the same time(s) daily.
  • Wind down mindfully: Engage in relaxing activities such as meditation or gentle stretching.
  • Focus on nutrition: Avoid caffeine and heavy meals late at night; include magnesium-rich foods.
  • Consider Magtein: May support relaxation, sleep quality, and next-day focus when paired with healthy sleep habits.*

Practicing these habits consistently can help you wake up feeling more refreshed, balanced, and ready to take on each day.*

References

  1. Liu G, Weinger JG, Lu ZL, et al. Magnesium-L-threonate supplementation improves memory and attention in older adults with cognitive complaints: a randomized, double-blind, placebo-controlled trial. J Alzheimers Dis. 2016;49(4):971–990.
  2. Abbasi B, Kimiagar M, Sadeghniiat K, et al. The effect of magnesium supplementation on primary insomnia in elderly: a double-blind placebo-controlled clinical trial. J Res Med Sci. 2012;17(12):1161–1169.
  3. Wienecke T, Nissen C, Schmidbauer K, et al. Effects of magnesium on sleep quality: a systematic review. Nutrients. 2020;12(10):3060.
  4. ClinicalTrials.gov. Magnesium L-Threonate for Anxiety, Mood, and Sleep Quality in Older Adults (NCT02363634). Available at: https://clinicaltrials.gov/ct2/show/NCT02363634

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The History of Magtein®: From Discovery to Innovation

 1024 679 Riley Forbes
By:
0

Magnesium plays a vital role in brain health. However, not all forms of magnesium can easily cross the blood-brain barrier to support cognitive function. Magtein (magnesium L-threonate) was created to overcome this challenge. Understanding its history reveals how scientific innovation can transform a well-known mineral into a brain-targeted supplement.*

The Discovery of Magnesium’s Role in the Brain

Magnesium has long been recognized as an essential mineral involved in more than 300 biochemical reactions throughout the body. Early research emphasized its importance in nerve signaling, synaptic plasticity, and learning.

However, most common forms – such as magnesium oxide or citrate – mainly support muscle and cardiovascular health. They have limited ability to raise magnesium levels in the brain. As research advanced, scientists began searching for new forms of magnesium that could effectively reach the brain to support cognitive performance.

Ultimately, researchers identified magnesium’s limited transport across the blood-brain barrier as a key barrier to its neurological benefits.

From scientific discovery to brain health innovation – Magtein® represents decades of magnesium research designed to enhance cognitive function and support better sleep.

The Development of Magnesium L-Threonate

To address the challenge of poor magnesium absorption in the brain, neuroscientists developed magnesium L-threonate. This compound combines magnesium with L-threonic acid, a metabolite of vitamin C that enhances magnesium’s ability to dissolve and move through the body.

This pairing increases solubility, meaning magnesium can dissolve more effectively in water and body fluids. Better solubility improves absorption through the digestive tract and helps magnesium travel across cell and brain membranes. This is especially important for the brain, where magnesium uptake is highly regulated. By improving both solubility and transport, magnesium L-threonate helps magnesium reach brain regions involved in focus, relaxation, and sleep regulation.*

Innovative Mechanism of Action

Human studies have shown that magnesium L-threonate can increase magnesium levels in the brain, thereby supporting essential processes related to learning, memory, and emotional balance.*

  • Synaptic plasticity and learning: Magnesium helps activate NMDA (N-methyl-D-aspartate) receptors, which are critical for learning and memory. These receptors regulate calcium flow between neurons, strengthening communication and adaptability. Consequently, balanced NMDA activity promotes effective learning responses and supports overall cognitive function.*
  • Neuronal stability: Magnesium also supports steady communication between brain cells by balancing excitatory and calming neurotransmitters. Furthermore, it helps prevent overstimulation and promotes calm, clear signaling. This, in turn, contributes to better focus, emotional steadiness, and cognitive clarity throughout the day.*
  • Sleep and emotional balance: Brain magnesium supports relaxation by influencing GABA (gamma-aminobutyric acid) pathways, which help calm neural activity before rest. Additionally, it plays a role in maintaining healthy circadian rhythms that guide natural sleep-wake cycles. Together, these effects support deeper, more restorative sleep and balanced emotional well-being.*

Because of this targeted mechanism, magnesium L-threonate differs from other forms of magnesium that primarily support muscles or energy metabolism. Instead, it delivers magnesium directly to the brain, thereby supporting mental clarity, relaxation, and quality rest as part of a balanced lifestyle.*unique design helps deliver magnesium to the brain, supporting mental clarity, calmness, and restorative rest as part of a balanced lifestyle.*

Key Milestones in Magtein Research

The development of Magtein has been marked by several critical studies demonstrating its efficacy in humans:

  • Cognitive benefits: In a trial led by Liu et al., older adults with subjective memory complaints showed significant improvements in working memory, attention, and executive function after 12 weeks of magnesium L-threonate supplementation.
  • Sleep and mood support: Hausenblas et al., demonstrated improved sleep quality, deep sleep duration, and reduced irritability in adults using magnesium L-threonate over several weeks.
  • Stress regulation: Ongoing clinical trials, including the study Magnesium L-Threonate for Anxiety, Mood, and Sleep Quality in Older Adults (NCT02363634), are investigating the role of brain magnesium in supporting emotional resilience.*

These studies highlight a continuum from discovery to practical application, demonstrating how scientific innovation can translate into meaningful, structure/function benefits for consumers.

Magtein in the Context of Healthy Aging

As people live longer, maintaining brain health and emotional balance becomes increasingly important. Magnesium L-threonate supports this goal by helping maintain healthy brain magnesium levels, which in turn promote:

  • Memory retention and learning*
  • Stress management and emotional well-being*
  • Restorative sleep and next-day focus*

Although research is ongoing, current evidence suggests that Magtein can be part of a science-backed approach to supporting healthy cognitive aging.*

Magtein supports cognitive clarity and healthy aging, reflecting ongoing research into magnesium’s vital role in memory, focus, and overall brain wellness.

Future Directions and Ongoing Research

Current studies continue to explore how magnesium L-threonate may benefit brain health in broader ways, including:

  • Long-term cognitive outcomes in adults over 70
  • Potential synergies with other nutrients for brain support
  • Mood and stress regulation across diverse populations

Future findings will help refine how magnesium L-threonate fits into holistic strategies for maintaining mental clarity, emotional balance, and sleep quality.*

The Takeaway

The history of Magtein illustrates the evolution of scientific discovery into practical innovation. By addressing the challenge of brain magnesium delivery, magnesium L-threonate supports memory, sleep, and emotional balance in adults.* Its development highlights the intersection of biochemistry, neuroscience, and nutritional science, providing a foundation for healthy aging and cognitive resilience.

References

  • Liu G, Weinger JG, Lu ZL, et al. Magnesium-L-threonate supplementation improves memory and attention in older adults with cognitive complaints: a randomized, double-blind, placebo-controlled trial. J Alzheimers Dis. 2016;49(4):971–990.
  • Hausenblas HA, Lynch T, Hooper S, et al. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: a randomized controlled trial. Sleep Med X. 2024;8:100121.
  • ClinicalTrials.gov. Magnesium L-Threonate for Anxiety, Mood and Sleep Quality in Older Adults (NCT02363634). https://clinicaltrials.gov/ct2/show/NCT02363634
  • Barbagallo M, Dominguez LJ. Magnesium and aging. Curr Pharm Des. 2010;16(7):832–839.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.