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Riley Forbes

Magtein® May Help Support Cognitive Performance and a Healthier “Brain Age”

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Understanding “Brain Age” and Cognitive Longevity

While chronological age is measured in years, brain age reflects how well your brain performs relative to your biological age. A person in their sixties, for instance, might have the mental sharpness of someone decades younger – or, conversely, may notice that memory and focus require a little more effort than before.

What is Brain Age?

Brain age isn’t a fixed measure. It’s influenced by genetics, lifestyle habits, nutrition, sleep quality, and how effectively the body manages stress. Over time, the brain naturally undergoes structural and chemical changes – including a gradual decline in synaptic density, changes in neurotransmitter activity, and reduced efficiency in neuronal communication. These shifts can affect how quickly we process information, form memories, and stay attentive.

The encouraging reality is that brain age can be supported. Through consistent, science-based lifestyle habits – such as regular physical activity, mental engagement, restorative sleep, and balanced nutrition – it’s possible to help maintain a “younger” cognitive profile well into later years.*

An active older couple walking along the beach, reflecting healthy aging, emotional well-being, and lifestyle habits that help support long-term cognitive vitality.

The Science of Cognitive Performance and Aging

Cognitive performance is the result of the brain’s ability to learn, adapt, and store new information – processes that depend on synaptic plasticity, or the flexibility and strength of connections between neurons.

Magnesium plays an essential role in supporting this process by helping regulate neuronal electrical activity and enzyme function involved in brain communication. However, brain magnesium levels tend to decline with age, and most dietary forms of magnesium are not efficiently absorbed into the brain due to the blood–brain barrier.

Magtein (magnesium L-threonate) was developed to effectively deliver magnesium to brain tissue, where it can support the cellular mechanisms underlying learning, memory, and cognitive flexibility.*

Researchers continue exploring how magnesium L-threonate supports memory, focus, and long-term brain function.

How Magtein May Help Support a Healthier “Brain Age”

Several human studies have investigated how magnesium L-threonate may support memory, learning, and attention – key components of cognitive performance.* By promoting healthy magnesium levels within brain cells, Magtein helps maintain neuronal density and supports the signaling pathways involved in focus and memory formation.*

Evidence from Human Studies on Magnesium L-Threonate

In a clinical study involving adults aged 50 to 70, daily supplementation with magnesium L-threonate was associated with improvements in cognitive performance measures and working memory compared to baseline results.* Participants also reported improved mood balance and reduced mental fatigue.*

Researchers suggest these findings may relate to magnesium’s ability to support synaptic plasticity – a foundational process for long-term brain health and adaptive learning.* By sustaining efficient communication between neurons, Magtein may help the brain “age better,” supporting clarity, recall, and resilience over time.*

Lifestyle Factors That Complement Magtein

Magtein can play a role in supporting cognitive health, but lifestyle and environmental choices remain equally important. Together, they create a foundation for maintaining an active and adaptable brain throughout life.

  • Prioritize Quality Sleep: Deep sleep supports memory consolidation and helps clear metabolic byproducts from the brain. Maintaining consistent sleep–wake cycles reinforces cognitive balance.
  • Engage in Mental Stimulation: Learning, reading, and creative pursuits challenge the brain, encouraging new neural connections.
  • Move Regularly: Physical activity promotes healthy blood flow to the brain and stimulates growth factors that maintain neuron vitality.
  • Manage Stress Thoughtfully: Chronic stress can influence neurotransmitter activity. Practices like meditation, deep breathing, and spending time outdoors can help promote calm and mental balance.
  • Nourish the Brain: A nutrient-dense diet rich in magnesium-containing foods (such as leafy greens, legumes, and nuts), omega-3 fatty acids, and antioxidants supports overall brain function and resilience.

Together with Magtein, these habits can help support cognitive performance and healthy brain aging from multiple angles.*

Lifestyle factors like sleep, exercise, and mindfulness can help support brain health alongside Magtein.

References

  1. Zhang C, Hu Q, Li S, Dai F, Qian W, Hewlings S, Yan T, Wang Y. A Magtein®, Magnesium L-Threonate–Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults. Nutrients. 2022;14(24):5235. doi:10.3390/nu14245235
  2. Hausenblas HA, Lynch T, Hooper S, Shrestha A, Rosendale D, Gu J. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: a randomized controlled trial. Sleep Med X. 2024;8:100121.
  3. Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010;65(2):165-177. doi:10.1016/j.neuron.2010.01.001
  4. Liu G, Weinger JG, Lu ZL, Xue F, Sadeghpour S. Efficacy and Safety of MMFS-01, a synapse density enhancer, for treating cognitive impairment in older adults: a randomized, double-blind, placebo-controlled trial. J Alzheimers Dis. 2015;49(4):971-990.

FDA Disclaimer

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Why Magtein® Is Different And Why That Matters

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What Is Magtein?

Magnesium is an essential mineral that supports hundreds of biological functions throughout the body, including energy metabolism, nerve signaling, and muscle health. However, not all forms of magnesium are created equal.

Magtein (magnesium L-threonate) is a patented form of magnesium studied for its ability to support cognitive health, sleep quality, and daytime focus.* Unlike other magnesium forms that primarily target muscle relaxation or digestive comfort, Magtein stands out for its unique ability to cross the blood-brain barrier and support brain function directly.*

A 2024 clinical trial published in Sleep Medicine X provided new insight into Magtein’s potential role in improving sleep quality and next-day wellness.* 

Let’s explore what makes this form of magnesium unique, why the science matters, and how it may fit into your daily routine!

Incorporating Magtein into your daily routine may help support cognitive clarity, restful sleep, and overall brain wellness.*

The Latest Research: Magtein and Sleep Quality

Key Findings from the 2024 Clinical Trial

In a randomized, controlled trial published in Sleep Medicine X (2024) titled Magnesium L-Threonate Improves Sleep Quality and Daytime Functioning in Adults with Self-Reported Sleep Problems: A Randomized Controlled Trial, researchers enrolled 80 adults aged 35-55 who reported sleep difficulties. Participants received magnesium L-threonate (Magtein) or placebo for 21 days. The study used validated questionnaires and objective wearable metrics to assess sleep and daytime functioning.

The findings included:

  • Participants taking magnesium L-threonate reported improved subjective sleep quality compared with placebo.*
  • Objective measures showed enhancements in deep sleep and REM sleep metrics, and participants reported better daytime energy and mood.*
  • Magnesium L-threonate was well tolerated, with no significant adverse effects reported.

These results build on earlier research suggesting magnesium L-threonate supports cognitive health and helps maintain a balanced sleep-wake rhythm, contributing to feelings of restoration and mental clarity.*

Clinical research suggests Magtein helps support balanced sleep–wake cycles for deeper rest and refreshed mornings.*

How Does Magtein Work?

Sleep and cognition are tightly interconnected. Magnesium helps regulate NMDA receptors – key channels that control how nerve cells communicate. When excitatory signaling becomes too high, it can interfere with both deep sleep and mental focus.

By supporting magnesium levels within the brain, Magtein helps:

  • Promote relaxation before bedtime, easing the transition into restful sleep.*
  • Support synaptic plasticity, which is essential for learning and memory during deep sleep.*
  • Maintain healthy circadian rhythm signaling, influencing daytime alertness and focus.*

In simpler terms, Magtein helps the brain “power down” at night and “power up” more effectively the next morning.*

What Makes Magtein Unique

If you’ve tried other magnesium supplements, you may have noticed that most focus on muscle recovery, bowel regularity, or cardiovascular support. While those benefits are valuable, not all magnesium forms effectively influence the brain.

For example:

  • Magnesium oxide – low absorption, often used for digestive health.
  • Magnesium citrate – supports regularity and hydration.
  • Magnesium glycinate – gentle on digestion, commonly used for relaxation.

Magtein is clinically shown to cross the blood-brain barrier, delivering magnesium directly to the brain – where it can support cognitive health, memory, and balanced mood.*

By crossing the blood–brain barrier, Magtein delivers magnesium directly where it supports cognition, memory, and mood balance.*

Dosage and Safety

In the 2024 trial, participants consumed magnesium L-threonate at doses consistent with those found in many high-quality dietary supplements. Typical daily servings provide 1-2 grams of magnesium L-threonate compound, delivering approximately 100-200 mg of elemental magnesium.

As with any supplement, follow product directions and consult a qualified healthcare professional before use – especially if you are pregnant, nursing, taking medication, or have a medical condition.*

What Sets Magtein Apart

Magtein’s strength lies in both its unique structure and its growing body of clinical research. The 2024 study adds to previous findings exploring magnesium L-threonate’s role in supporting memory, learning, and cognitive performance over time.* This consistency reflects Magtein’s ongoing commitment to scientific validation and transparency – qualities that distinguish it in the nutritional supplement landscape.

The Takeaway: A Smarter Magnesium for Brain and Sleep

When it comes to magnesium, form matters. Magtein (magnesium L-threonate) stands apart as a science-backed form that supports sleep quality, morning focus, and overall cognitive health.*

Backed by peer-reviewed research – including the most recent 2024 clinical trial – Magtein represents more than mineral support. It reflects the next generation of magnesium innovation, designed for the brain.

For those seeking a supplement that’s both effective and scientifically validated, Magtein is a trusted choice grounded in research and transparency.*

References

  1. Hausenblas HA, Lynch T, Hooper S, Shrestha A, Rosendale D, Gu J. Magnesium L-Threonate Improves Sleep Quality and Daytime Functioning in Adults with Self-Reported Sleep Problems: A Randomized Controlled Trial. Sleep Med X. 2024;6:100121.
  2. Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of Learning and Memory by Elevating Brain Magnesium. Neuron. 2010;65(2):165–177.

FDA Disclaimer

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.