Find us in 500+ SKUs
100K+ 5-star reviews on Amazon
Sold in 50+ countries
Find us in 500+ SKUs
100K+ 5-star reviews on Amazon
10+ years of research
Sold in 50+ countries
Brain Health
Supports cognitive vitality*
Better Magnesium.
Better Brain.™
Magtein® is the unique, patented form of magnesium L-threonate, shown in studies to support brain health and cognitive vitality, backed by transparent science, human clinical research, and global recognition for scientific innovation*
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Find us in 500+ SKUs
100K+ 5-star reviews on Amazon
10+ years of research50M+ bottles sold
Sold in 50+ countriesMagtein® Benefits
Scroll to explore
Sleep
Supports restful sleep*
Energy
Supports sustained energy*
Focus
Supports mental clarity*
Mood
Supports emotional balance*
Memory
Supports recall*
Magtein® vs. Other Magnesiums
Not all forms of magnesium work the same way.
Feature
Magtein® (L-Threonate)
Other Magnesiums(e.g., Glycinate, Citrate, Oxide)
Brain-targeted delivery
High
Shown in research to reach the brain — brain-health mechanism tied to its L-threonate component.*
Shown in research to reach the brain — brain-health mechanism tied to its L-threonate component.*
Limited
Not all forms work the same way. Many may not effectively reach the brain.*
Not all forms work the same way. Many may not effectively reach the brain.*
Cognitive support
Backed
Supports working memory, reaction time, and cognitive performance.
Supports working memory, reaction time, and cognitive performance.
Indirect
May support overall well-being, but cognitive benefits are less direct and less studied.*
May support overall well-being, but cognitive benefits are less direct and less studied.*
Published research
40+ studies
40+ peer-reviewed publications, 5 human clinical trials. Most published human research of any magnesium form for brain health.*
40+ peer-reviewed publications, 5 human clinical trials. Most published human research of any magnesium form for brain health.*
Limited
Often supported by general magnesium research, not form-specific brain studies.*
Often supported by general magnesium research, not form-specific brain studies.*
Form quality
Premium
A uniquely studied form — well-tolerated with fewer GI side effects compared to high-dose forms.*
A uniquely studied form — well-tolerated with fewer GI side effects compared to high-dose forms.*
Varies
Many products boost “elemental magnesium” by adding poorly absorbed magnesium oxide (MgO).*
Many products boost “elemental magnesium” by adding poorly absorbed magnesium oxide (MgO).*
Our Journey
Scroll to exploreMore than 15 years of pioneering research have made Magtein® synonymous with brain health.
2010Discovered
Neuroscientists led by Dr. Guosong Liu publish landmark research in the journal Neuron, identifying magnesium L-threonate as a novel compound shown to raise brain magnesium levels and enhance synaptic plasticity and memory in animal models.¹
2011GRAS Self-Affirmed
Magtein is self-affirmed as GRAS (Generally Recognized As Safe) under FDA guidelines.
2016First Human
Clinical Trials
Clinical Trials
Clinical research in older adults with cognitive complaints shows measurable improvement in processing speed, establishing Magtein's first published human evidence base.²
2022Research Expands
A new peer-reviewed human clinical study, published in Nutrients, shows a Magtein-based formula improves memory in healthy adults, with the largest gains seen in older participants.³
2024Sleep Quality
Trial Published
Trial Published
A randomized, controlled trial (Hausenblas et al., Sleep Medicine X) finds that Magtein improves sleep quality and daytime functioning in adults with self-reported sleep problems, including gains in deep sleep, REM sleep, and next-day mood and alertness.⁴
2026Cognitive Performance
Trial Published
Trial Published
Approved for medical and consumer wellness use across key European and Asian health networks.
References: 1. Slutsky I, et al. 2010., 2. Liu G, et al. 2016., 3. Wang Y. 2022., 4. Hausenblas HA, et al. 2024., 5. Lopresti AL, Smith SJ. 2026.
Awards and Recognition
Cognitive and Emotional Health Ingredient of the Year
Nutrition Research Project of the Year
Ingredient of the Year, Mind & Mood
Ingredient of the
Year, Healthspan
Ingredient of the
Year, Healthspan
Ingredient of the
Year, Mind & Mood
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