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Rafea Naffa, PhD — Director of R&D

Magnesium for women across life stages, sleep and brain health

Magnesium for Women: Life Stages, Sleep & Brain Health

 1024 683 Rafea Naffa, PhD — Director of R&D
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The best magnesium for women depends on your goal. To close the everyday intake gap—and many women have one—any well-absorbed dietary form helps support energy, nerves, and muscle function.* But if your goals are calm focus, sleep quality, and healthy brain aging, the form matters as much as the dose. Magnesium L-threonate (Magtein®) is the brain-targeted form studied in human trials for cognition and sleep quality.

Direct answer

Women’s magnesium needs change across life stages, and low intake remains common. Food should provide the foundation. For women interested in calm focus, sleep quality, and healthy cognitive aging, Magtein® is the brain-targeted magnesium form studied in adult cognition and sleep trials.*

Magnesium for women: at a glance

Daily foundationMagnesium contributes to normal energy-yielding metabolism, nervous-system function, psychological function, muscle function, and the reduction of tiredness and fatigue.*
Daily targetMost adult women need about 310–320 mg/day; needs rise during pregnancy and may differ during lactation.
A common shortfallLow magnesium intake is common in women and persists across reproductive and menopausal years.
Hormonal life stagesMagnesium does not balance hormones directly. Adequacy may support women through hormonal life stages by contributing to normal energy metabolism, nervous-system function, psychological function, and the reduction of tiredness and fatigue.*
Brain-targeted formThe brain is protected by the blood-brain barrier; Magtein was developed as a brain-targeted form.
Human researchIn human trials, Magtein was studied for cognition, sleep quality, and recovery-related measures in adults.

What does magnesium do in the body?

Magnesium is a cofactor in hundreds of enzymatic reactions—the quiet chemistry behind energy production, nerve signaling, and muscle function.

Recognized roles of magnesium include contributing to:*

  • normal energy-yielding metabolism
  • the reduction of tiredness and fatigue
  • normal functioning of the nervous system
  • normal psychological function
  • normal muscle function
  • electrolyte balance

Because magnesium has broad roles, low intake may be associated with general wellness concerns such as energy, sleep quality, and stress resilience, rather than one obvious sign.

Why do so many women fall short on magnesium?

Most adult women need about 310–320 mg/day [2]—yet low magnesium intake is common in women, and it persists across life stages.

A national US survey analysis found that intake from food fell below the Estimated Average Requirement for magnesium in about 62% of younger women aged 15–30, 44% of women aged 31–44, 50% of perimenopausal women aged 40–50, and 49% of menopausal women aged 51–65 [1]. Roughly half of US adults overall don’t meet the recommended intake [2].

Important distinction: None of that means most women are “deficient” in a clinical sense. It means there’s a wide, under-recognized gap between getting enough to avoid a problem and getting enough to feel your best—and food is where to start closing it.

How does magnesium support women’s hormonal transitions?

Magnesium is not a hormone, and it shouldn’t be described as a hormone-balancing treatment. But it is closely connected to the systems women rely on during hormonal transitions.

Women’s nutritional needs change across reproductive years, pregnancy, breastfeeding, perimenopause, menopause, and later life [4]. Research also suggests that hormonal status, including estrogen changes, can influence how magnesium is absorbed, distributed, and retained [3]. That means magnesium adequacy may become especially relevant during life stages when women are focused on energy, sleep quality, stress resilience, normal psychological function, and healthy brain aging.

For women, the goal isn’t to “control hormones” with magnesium. It’s to support the body’s normal systems during periods of change: energy-yielding metabolism, normal nervous-system function, normal psychological function, normal muscle function, and the reduction of tiredness and fatigue.* That’s why magnesium belongs in the conversation about women’s life-stage nutrition.

This does not mean magnesium treats hormone-related symptoms. It means magnesium is part of the nutritional foundation women may want to pay closer attention to during hormonal transitions.

What should women know during pregnancy and lactation?

Magnesium needs rise during pregnancy and may differ during lactation. If you are pregnant, breastfeeding, or planning to be, focus on a varied, magnesium-rich diet and speak with your healthcare professional before starting any supplement. They can advise on what’s appropriate for you. This section is about nutritional needs, not a recommendation for any specific product.

Why do perimenopause and menopause put brain health in focus?

During perimenopause and menopause, many women become more focused on sleep quality, stress resilience, energy, and protecting long-term brain health. As noted above, many women also aren’t meeting their intake targets [1].

This is where magnesium’s role above the neck matters. The brain is sensitive to magnesium, which helps regulate the receptors involved in learning, memory, and a calm nervous system. Magnesium contributes to normal nervous-system function and normal psychological function—aligning with what many women want through midlife: steady focus, an easier wind-down, and support for healthy brain aging.*

There’s also a population-level signal: a large UK brain-imaging study of adults aged 40–73 found higher dietary magnesium intake was associated with larger brain volumes and fewer white-matter lesions, with notable sex differences [5]. This is observational, food-based evidence—not a Magtein study and not proof of cause—but it reinforces why keeping magnesium topped up across the lifespan is a sensible habit.

Why does the form of magnesium matter for the brain?

Your brain has a natural gatekeeper—the blood-brain barrier—that carefully controls what enters from the bloodstream. Because the brain is protected by this barrier, researchers have studied whether specific magnesium forms may better support brain magnesium biology. Direct brain-magnesium elevation has not been established for common supplemental forms in humans.

What has preclinical research shown?

Magnesium L-threonate (Magtein) was developed for this brain-targeted magnesium research area. Preclinical studies reported increased brain magnesium after magnesium L-threonate, alongside changes in the structure and function of neurons in regions tied to memory and emotional regulation [6]. That is why Magtein is positioned as a brain-targeted magnesium form and provides magnesium in a form developed for this research area.

Worth knowing: Magtein is not a high-dose elemental magnesium product. A typical 2 g/day serving provides roughly 145 mg of elemental magnesium, making it a brain-targeted source of magnesium for everyday use while staying well below the 350 mg/day tolerable upper level for supplemental magnesium.* Loose stools are the most common sign of taking too much supplemental magnesium.

What does the Magtein human research show?

Mixed-sex adult trials that included women have studied Magtein for cognition, sleep quality, and recovery-related measures. These findings describe research outcomes, not promises.

2024 sleep study

In a randomized controlled trial, 80 adults aged 35–55 with self-reported sleep problems took Magtein for three weeks. The trial reported improvements in sleep-quality measures—including deep-sleep and REM sleep scores from a wearable ring—and in next-day functioning. The supplement was well tolerated [7].

2026 cognition and sleep study

In a randomized, double-blind, placebo-controlled trial, 100 healthy adults aged 18–45 took 2 g/day of Magtein or placebo for six weeks. Cognition was measured by the NIH Toolbox. The trial reported greater improvements in overall cognitive performance—including working memory and reaction time—in the Magtein group versus placebo, alongside changes in night-time heart rate and heart-rate variability [8].

How should women interpret the findings?

The night-time measures are recovery-related physiological outcomes. The 2026 study also described an exploratory cognitive-age estimate derived from the study model. For everyday use, the practical message is support for cognitive wellness, next-day clarity, and recovery-related measures.*

Read the full 2026 Magtein® clinical-trial review for a closer look at the study design, cognition, sleep, and HRV findings.

Across these studies, the through-line is consistent: a brain-targeted form, studied in humans for cognition, sleep quality, and recovery. That makes Magtein a relevant option for women interested in brain-focused magnesium support.*

How can women bridge the magnesium gap?

1

Food first. Build the base with leafy greens, legumes, nuts, seeds, and whole grains—among the densest everyday sources.

2

Look beyond diet. Factors like certain medications, digestive issues, heavy sweating, and restrictive eating can also lower magnesium or raise needs.

3

Match the form to the goal. For everyday cognitive wellness, magnesium L-threonate (Magtein) is the brain-targeted magnesium form studied for cognition, focus, sleep quality, and recovery-related measures.*

4

Mind the upper limit. A typical 2 g/day serving of Magtein provides about 145 mg of elemental magnesium, keeping it well below the 350 mg/day tolerable upper level for supplemental magnesium. Loose stools are the most common sign of taking too much supplemental magnesium.

5

Check before you supplement if you are pregnant or breastfeeding, have kidney disease, or take regular medication.

Frequently asked questions about magnesium for women

Choosing a magnesium form

What is the best magnesium for women?

It depends on your goal. For general intake, any well-absorbed form helps close the common shortfall and supports normal energy metabolism, nerve, and muscle function.* For cognition, focus, and sleep specifically, magnesium L-threonate (Magtein) is the brain-targeted magnesium form studied for those goals and can fit into an everyday cognitive-wellness routine.* Many women do well with both: a food-first foundation plus a brain-targeted form for cognitive goals.

Daily needs and life stages

How much magnesium do women need per day?

Most adult women need about 310–320 mg of magnesium per day from food and supplements combined, with higher needs during pregnancy and individualized guidance during lactation. Because the body absorbs only part of what you eat and many women fall short from food alone, supplements can help close the gap. Keep supplemental magnesium within the 350 mg/day upper limit.

Why do women’s magnesium needs change as they age?

Women’s nutritional needs shift across reproductive years, pregnancy, perimenopause, menopause, and later life. Research also suggests that hormonal status, including estrogen, can influence how magnesium is absorbed and retained. That makes magnesium adequacy worth paying closer attention to during these transitions—alongside the everyday intake gap many women already have.

Hormones, sleep, stress and pregnancy

Does magnesium help with hormones, sleep, and stress?

Magnesium is not a hormone, but it supports normal nervous-system function and normal psychological function, which matter during hormonal life stages.* In trials, Magtein has been studied for sleep quality, next-day functioning, and cognition in adults. Think of magnesium as nutritional support for the body’s normal systems during periods of change, not as a treatment for a sleep, mood, or hormone-related condition.

Is magnesium safe to take during pregnancy?

Magnesium needs rise in pregnancy, but you should speak with your healthcare professional before starting any supplement so they can advise on what’s right for you.

Magnesium for women: the bottom line

Magnesium is a foundational nutrient for women—needed in different amounts across life stages, widely under-consumed, and easy to support through food. But if your goal is calm focus, sleep quality, and healthy brain aging, the form matters more than the marketing.

Magnesium L-threonate (Magtein) is the brain-targeted form studied for those goals. Start with your plate, know your number for your life stage, and match your form to your goal.*

Related Magtein® reading

Signs and Symptoms of Magnesium Deficiency Your Optimal Sleep Routine Magtein® vs Magnesium Glycinate

References

Women’s nutrition and life stages

1. Devarshi PP, Legette LL, Grant RW, Mitmesser SH. Total estimated usual nutrient intake and nutrient status biomarkers in women of childbearing age and women of menopausal age. Am J Clin Nutr. 2021;113(4):1042–1052. doi:10.1093/ajcn/nqaa392.

2. National Institutes of Health, Office of Dietary Supplements. Magnesium — Health Professional Fact Sheet.

3. Mazza E, Maurotti S, Ferro Y, et al. Magnesium: Exploring Gender Differences in Its Health Impact and Dietary Intake. Nutrients. 2025;17(13):2226. doi:10.3390/nu17132226.

4. Porri D, Biesalski HK, Limitone A, Bertuzzo L, Cena H. Effect of magnesium supplementation on women’s health and well-being. NFS Journal. 2021;23:30–36. doi:10.1016/j.nfs.2021.03.003. Narrative review; background framing only.

Brain, sleep and cognition research

5. Alateeq K, Walsh EI, Cherbuin N. Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences. Eur J Nutr. 2023;62:2039–2051. doi:10.1007/s00394-023-03123-x.

6. Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010;65(2):165–177. doi:10.1016/j.neuron.2009.12.026. Preclinical.

7. Hausenblas HA, Lynch T, Hooper S, et al. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: a randomized controlled trial. Sleep Med X. 2024;8:100121. doi:10.1016/j.sleepx.2024.100121.

8. Lopresti AL, Smith SJ. The effects of magnesium L-threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial. Front Nutr. 2026. doi:10.3389/fnut.2025.1729164.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Individual needs vary; consult a healthcare professional before using supplements, especially during pregnancy or lactation, with kidney disease, or when taking medication.

Magnesium for men supporting energy, sleep and daily performance

Magnesium for Men’s Health: Energy, Sleep & Daily Performance

 1024 683 Rafea Naffa, PhD — Director of R&D
By:
0

The best magnesium for men depends on your goal. Men actually need more magnesium than women—yet many fall short of the recommended target. To close that everyday gap, any well-absorbed dietary form supports energy, nerves, and muscle function.* But if your goals include focus, sleep quality, mental clarity, and healthy brain aging, the form matters as much as the dose. Magnesium L-threonate (Magtein®) is the brain-targeted form studied in human trials for cognition and sleep quality.

What this guide covers

This guide covers how much magnesium men actually need, why so many come up short, why the form matters for the brain, and what the research shows.

Magnesium for men: at a glance

Daily foundationFor men’s health, magnesium supports energy metabolism, muscle function, electrolyte balance, nervous-system function, psychological function, and reduction of tiredness and fatigue.*
Male physiologyMagnesium is part of the nutritional foundation for male physiology, while testosterone and fertility research remain emerging areas of background science.
Daily targetMost adult men need about 400–420 mg/day—more than women—yet average intake runs closer to ~340 mg.
A common shortfallUS data suggest many adults fall short, and a 2024 global modelling analysis estimated inadequate magnesium intake in about 2.4 billion people worldwide, with higher inadequacy in males than females.
Needs can varyOlder men and very active men may need more or absorb less, widening the gap.
Brain-targeted formThe brain is protected by the blood-brain barrier; Magtein was developed as a brain-targeted form.
Human researchIn human trials that included men, Magtein was studied for cognition, sleep quality, and recovery-related measures—not treatment for any condition.

What does magnesium do in the body?

Magnesium is a cofactor in hundreds of enzymatic reactions—the quiet chemistry behind energy production, nerve signaling, and muscle function.

Recognized roles of magnesium include contributing to:*

  • normal energy-yielding metabolism
  • the reduction of tiredness and fatigue
  • normal functioning of the nervous system
  • normal psychological function
  • normal muscle function
  • electrolyte balance

Because magnesium has broad roles, low intake may be associated with general wellness concerns such as energy, sleep quality, and stress resilience, rather than one obvious sign.

Why do men need more magnesium—and often get less?

Men need more magnesium than women, largely because of body size and muscle mass. US guidelines set the target for adult men at about 400–420 mg/day, compared with 310–320 mg for women [1]. The catch is that men, on average, don’t hit it: average magnesium intake in US men runs closer to ~340 mg/day—below the full recommendation [2].

The body absorbs only about 30–40% of dietary magnesium [1], so the shortfall is easy to land in. Roughly half of US adults fall short of the recommended intake overall [1], [2].

Low magnesium intake is not only a US issue. A 2024 global modelling analysis in The Lancet Global Health estimated that about 2.4 billion people worldwide—roughly 31% of the global population—had inadequate magnesium intake from food. Importantly for men’s health, the analysis found that inadequate magnesium intake was consistently higher in males than females within the same country and age group [3]. Because this analysis excluded fortification and supplementation, it should be understood as food-intake inadequacy rather than clinical deficiency.

Why do some men fall short?

Two patterns make men especially prone to coming up short. First, diets heavy in processed foods and refined grains—the “Western” pattern men tend to follow more than women—are low in the whole grains, legumes, nuts, seeds, and greens that supply magnesium [4].

Second, older and very active men can need more or absorb less: aging can reduce absorption and increase urinary loss, while heavy training raises losses through sweat and urine [4]. None of this means most men are “deficient” in a clinical sense. It means there’s a wide, under-recognized gap between getting enough to avoid a problem and getting enough to feel your best.

How does magnesium for men support energy, sleep and daily performance?

Magnesium is not just a “muscle mineral” or a sleep supplement. For men, it is part of the daily health foundation. It contributes to normal energy-yielding metabolism, normal muscle function, electrolyte balance, normal nervous-system function, normal psychological function, and the reduction of tiredness and fatigue.*

These roles matter for men balancing work, training, family responsibilities, daily pressure, activity, and recovery. Many men first think about magnesium in relation to muscle function, training, or exercise. That connection makes sense because magnesium contributes to normal muscle function and electrolyte balance.*

But the bigger men’s-health picture is broader: magnesium also supports the nervous system, energy metabolism, and psychological function—areas that connect directly to focus, sleep quality, daily resilience, and healthy aging.*

Body-to-brain connection: This is where the men’s-health story moves from the body to the brain. General magnesium adequacy supports the whole-body foundation.* Men looking specifically for focus, mental clarity, sleep quality, and healthy cognitive aging may want a brain-targeted magnesium form. Magnesium L-threonate (Magtein) is the form studied in human trials for cognition, sleep quality, and recovery-related measures.

What does research say about magnesium and male physiology?

Magnesium is often discussed in men’s health because of its connection to energy metabolism, muscle function, physical function, and male physiology. Some research has explored links between magnesium status and testosterone bioactivity, especially in older men and physically active men. The evidence is still emerging, so this is best treated as background science rather than a direct benefit claim [5].

A recent study in infertile men reported that higher serum magnesium was associated with higher sperm concentration, total sperm count, motile sperm count, progressively motile sperm count, and serum anti-Müllerian hormone. The same study found no clear difference in total testosterone, free testosterone, FSH, LH, or inhibin B across magnesium tertiles. A longitudinal analysis also did not show that changes in serum magnesium led to changes in semen parameters. This makes the story scientifically interesting, but still early [6].

For everyday men’s health, the practical message remains simple: magnesium supports normal energy metabolism, normal muscle function, electrolyte balance, normal nervous-system function, normal psychological function, and reduction of tiredness and fatigue.* For brain-focused daily support, Magtein remains the magnesium form studied for cognition, sleep quality, and recovery-related measures.

Why does the form of magnesium matter for the brain?

Magnesium’s most overlooked role is above the neck. It sits at the center of the calcium–magnesium balance that governs how active and reactive your brain cells are, and it helps regulate the receptors involved in learning, memory, and a calm, focused mental state. Magnesium contributes to normal functioning of the nervous system and normal psychological function—which maps onto what many men actually want from it: steady focus, an easier wind-down, and support for healthy brain aging.*

But here’s the catch that decides everything. Your brain has a natural gatekeeper—the blood-brain barrier—that carefully controls what enters from the bloodstream. Because the brain is protected by this barrier, researchers have studied whether specific magnesium forms may better support brain magnesium biology. Direct brain-magnesium elevation has not been established for common supplemental forms in humans.

What has preclinical research shown?

Magnesium L-threonate (Magtein) was developed for this brain-targeted magnesium research area. Preclinical studies reported increased brain magnesium after magnesium L-threonate, alongside changes in the structure and function of neurons in regions tied to memory and decision-making [7].

To be precise, direct brain-magnesium elevation has been demonstrated in preclinical research and is inferred in humans. That is why Magtein is positioned as a brain-targeted form and provides magnesium in a form developed for this research area.

Magtein is not a high-dose elemental magnesium product. A typical 2 g daily serving provides roughly 145 mg of elemental magnesium. This makes it a brain-targeted source of magnesium for everyday cognitive wellness while staying well below the 350 mg/day tolerable upper level for supplemental magnesium.*

What does the Magtein human research show?

Mixed-sex adult trials that included men have studied Magtein for cognition, sleep quality, and recovery-related measures. These findings describe research outcomes, not promises.

2024 sleep study

In a randomized controlled trial, 80 adults aged 35–55 with self-reported sleep problems took Magtein for three weeks. The trial reported improvements in sleep-quality measures—including deep-sleep and REM sleep scores from a wearable ring—and in next-day functioning. The supplement was well tolerated [8].

2026 cognition and sleep study

In a randomized, double-blind, placebo-controlled trial, 100 healthy adults aged 18–45 took 2 g/day of Magtein or placebo for six weeks. Cognition was measured by the NIH Toolbox. The trial reported greater improvements in overall cognitive performance—including working memory and reaction time—in the Magtein group versus placebo, alongside changes in night-time heart rate and heart-rate variability [9].

How should men interpret the newer findings?

Those last two outcomes are recovery-related physiological measures, which may be relevant to men interested in daily readiness and recovery. The study also described an exploratory cognitive-age estimate derived from the study model. This younger, good-sleeper group showed no significant objective sleep-stage differences. Therefore, the most consistent everyday message is support for cognitive wellness, next-day clarity, and recovery-related measures, with sleep quality as a qualified secondary benefit.*

Read the full 2026 Magtein® clinical-trial review for a closer look at the study design, cognition, sleep and HRV findings.

There’s also a population-level signal: a large UK brain-imaging study of adults aged 40–73 found higher dietary magnesium intake was associated with larger brain volumes and fewer white-matter lesions, with notable sex differences [10]. This is observational, food-based evidence—not a Magtein study and not proof of cause—but it reinforces why keeping magnesium topped up across the decades is a sensible habit.

Across these studies, the through-line is consistent: a brain-targeted form, studied in humans for cognition, sleep quality, and recovery. That makes Magtein a relevant option for men interested in brain-focused magnesium support.*

How can men bridge the magnesium gap?

1

Food first. Build the base with leafy greens, legumes, nuts, seeds, and whole grains—among the densest everyday sources.

2

Mind the patterns that drain it. Heavily processed diets, heavy sweating from training, and high alcohol intake can all lower magnesium or raise needs.

3

Match the form to the goal. For everyday cognitive wellness, magnesium L-threonate (Magtein) is the brain-targeted magnesium form studied for cognition, focus, sleep quality, and recovery-related measures.*

4

Mind the upper limit. A typical 2 g/day serving of Magtein provides about 145 mg of elemental magnesium, keeping it well below the 350 mg/day tolerable upper level for supplemental magnesium. Loose stools are the most common sign of taking too much supplemental magnesium.

5

Check before you supplement if you have kidney disease or take regular medication.

Frequently asked questions about magnesium for men

Daily magnesium needs

How much magnesium should a man take per day?

Most adult men need about 400–420 mg of magnesium per day from all sources—more than women. Average intake in US men tends to run lower, around 340 mg, so many fall short. Because the body absorbs only part of what you eat, food-first sources plus a supplement can help close the gap. Keep supplemental magnesium within the 350 mg/day upper limit, and check with a professional if you have kidney concerns or take medications.

Brain-focused goals

Is Magtein magnesium L-threonate good for men?

Magnesium L-threonate (Magtein) is a brain-targeted form studied in healthy adults—men included—for cognition, sleep quality, and recovery-related measures. It is a relevant option for men whose goals are brain-focused, like focus, mental clarity, and healthy brain aging.* For general magnesium needs, food-first sources and well-absorbed dietary forms also work well.

Which magnesium is best for focus and mental clarity?

For brain-focused goals, magnesium L-threonate (Magtein) is the form developed for brain-targeted magnesium research and studied in adults for cognition, sleep quality, and recovery-related measures. Magnesium supports normal psychological function and nervous-system function as part of healthy daily routines.*

Timing, comparisons and male physiology

When is the best time for a man to take magnesium?

It depends on the form and your goal. Magtein is often used daily according to product directions; consistency matters more than precise timing, and taking magnesium with food can help if a particular form is hard on your stomach.

Is Magtein magnesium L-threonate better than glycinate or citrate for men?

They serve different goals rather than one being universally “better.” Glycinate and citrate are common, well-tolerated forms for general magnesium support. Magnesium L-threonate (Magtein) can also support general magnesium intake and is the form developed for brain-targeted magnesium research.* The right pick depends on whether your priority is overall magnesium status or cognitive, focus, and sleep-related goals. See the detailed comparison of Magtein® and magnesium glycinate.

How is magnesium connected to male physiology?

Magnesium is involved in energy metabolism, muscle function, nervous-system function, and normal psychological function.* Some research has also explored relationships between magnesium status, testosterone bioactivity, and semen parameters, but this area is still emerging. For daily use, the strongest message is magnesium’s established role as part of the nutritional foundation for men’s health.

The bottom line

Magnesium is a foundational nutrient for men’s health—supporting energy metabolism, muscle function, nervous-system function, psychological function, sleep quality, daily performance, and reduction of tiredness and fatigue.* The links between magnesium, testosterone bioactivity, and male fertility remain areas of emerging research.

But if the goal is everyday cognitive wellness, focus, sleep quality, and healthy brain aging, form matters. Magnesium L-threonate (Magtein) is the brain-targeted magnesium form studied for those goals and can fit into a daily routine built on food-first magnesium intake.*

Related Magtein® reading

Signs and Symptoms of Magnesium Deficiency
Your Optimal Sleep Routine
2026 Magtein® Clinical Trial Review

References

Daily needs and men’s health

1. National Institutes of Health, Office of Dietary Supplements. Magnesium — Health Professional Fact Sheet. RDA: men 400–420 mg; absorption ~30–40%; food sources; UL 350 mg supplemental.

2. Rosanoff A. Perspective: US Adult Magnesium Requirements Need Updating: Impacts of Rising Body Weights and Data-Derived Variance. Adv Nutr. 2021;12(2):298–304. doi:10.1093/advances/nmaa140.

3. Passarelli S, Free CM, Shepon A, Beal T, Batis C, Golden CD. Global estimation of dietary micronutrient inadequacies: a modelling analysis. Lancet Glob Health. 2024;12(10):e1590–e1599. doi:10.1016/S2214-109X(24)00276-6.

4. Mazza E, Maurotti S, Ferro Y, et al. Magnesium: Exploring Gender Differences in Its Health Impact and Dietary Intake. Nutrients. 2025;17(13):2226. doi:10.3390/nu17132226.

5. Maggio M, De Vita F, Lauretani F, et al. The interplay between magnesium and testosterone in modulating physical function in men. Int J Endocrinol. 2014;2014:525249. doi:10.1155/2014/525249.

6. Yahyavi SK, Probst-Drejer B, Poulsen NN, et al. Serum magnesium is linked with sperm concentration, motile sperm count and serum anti-Müllerian hormone in infertile men. Reprod Biomed Online. 2026;52(3):105232. doi:10.1016/j.rbmo.2025.105232.

Brain, sleep and cognition research

7. Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010;65(2):165–177. doi:10.1016/j.neuron.2009.12.026. Preclinical.

8. Hausenblas HA, Lynch T, Hooper S, et al. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: a randomized controlled trial. Sleep Med X. 2024;8:100121. doi:10.1016/j.sleepx.2024.100121.

9. Lopresti AL, Smith SJ. The effects of magnesium L-threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial. Front Nutr. 2026. doi:10.3389/fnut.2025.1729164.

10. Alateeq K, Walsh EI, Cherbuin N. Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences. Eur J Nutr. 2023;62:2039–2051. doi:10.1007/s00394-023-03123-x.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Individual needs vary; consult a healthcare professional before using supplements, especially with kidney disease or when taking medication.